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Clove

What is it?

Clove (Syzygium aromaticum) is a tree native to Indonesia. Its dried flower buds are a popular spice and are also used in Chinese and Ayurvedic medicine.

Clove oils, dried flower buds, leaves, and stems are used to make medicine. Clove oil contains a chemical called eugenol that might help decrease pain and fight infections. Clove is also a popular ingredient in cigarettes.

People commonly use clove for toothache, pain during dental work, dental plaque, hangover, indigestion, and many other conditions, but there is no good scientific evidence to support these uses.

How effective is it?

Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.

The effectiveness ratings for CLOVE are as follows:

Possibly effective for...

  • Pneumonia in people on breathing machines in the hospital. Use of a clove mouthwash might prevent pneumonia in people on breathing machines in the hospital.
There is interest in using clove for a number of other purposes, but there isn't enough reliable information to say whether it might be helpful.

Is it safe?

When taken by mouth: Clove is commonly consumed in foods. There isn't enough reliable information to know if taking clove in larger amounts is safe or what the side effects might be.

When applied to the skin: Clove oil or cream containing clove flower is possibly safe. But applying clove oil in the mouth or on the gums can sometimes cause irritation and gum damage. Applying clove oil or cream to the skin can sometimes cause burning and skin irritation.

When inhaled: Smoke from clove cigarettes is likely unsafe and can cause side effects such as breathing problems and lung disease.

Special precautions & warnings:

Pregnancy and breast-feeding: Clove is commonly consumed in foods. There isn't enough reliable information to know if clove is safe to use in larger amounts when pregnant or breast-feeding. Stay on the safe side and stick to food amounts.

Children: Clove oil is likely unsafe to take by mouth. Even small amounts of clove oil can cause severe side effects such as seizures, liver damage, and fluid imbalances.

Bleeding disorders: Clove oil contains a chemical called eugenol that seems to slow blood clotting. Taking clove oil might cause bleeding in people with bleeding disorders.

Surgery: Cloves contain chemicals that might affect blood sugar levels and slow blood clotting. It might interfere with blood sugar control or cause bleeding during or after surgery. Stop using clove at least 2 weeks before a scheduled surgery.

Are there interactions with medications?

Moderate
Be cautious with this combination.
Medications for diabetes (Antidiabetes drugs)
Clove might lower blood sugar levels. Taking clove along with diabetes medications might cause blood sugar to drop too low. Monitor your blood sugar closely.
Minor
Be watchful with this combination.
Ibuprofen (Advil, others)
Adding ibuprofen to clove oil before applying it to the skin might increase how much ibuprofen gets absorbed through the skin, possibly increasing side effects.
Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs)
Clove might slow blood clotting. Taking clove along with medications that also slow blood clotting might increase the risk of bruising and bleeding.

Are there interactions with herbs and supplements?

Herbs and supplements that might lower blood sugar
Clove might lower blood sugar. Taking it with other supplements with similar effects might lower blood sugar too much. Examples of supplements with this effect include aloe, bitter melon, cassia cinnamon, chromium, and prickly pear cactus.
Herbs and supplements that might slow blood clotting
Clove might slow blood clotting and increase the risk of bleeding. Taking it with other supplements with similar effects might increase the risk of bleeding in some people. Examples of supplements with this effect include garlic, ginger, ginkgo, nattokinase, and Panax ginseng.

Are there interactions with foods?

There are no known interactions with foods.

How is it typically used?

Clove is a spice commonly used in foods. It's also available in mouthwashes, gels, creams, and oils. As medicine, there isn't enough reliable information to know what an appropriate dose of clove might be. Speak with a healthcare provider to find out what type of product and dose might be best for a specific condition.

Other names

Bourgeon Floral de Clou de Girofle, Bouton Floral de Clou de Girofle, Caryophylli Flos, Caryophyllum, Caryophyllus aromaticus, Clavo de Olor, Clous de Girolfe, Clove Flower, Clove Flowerbud, Clove Leaf, Clove Oil, Clove Stem, Cloves, Cloves Bud, Ding Xiang, Eugenia aromatica, Eugenia caryophyllata, Eugenia caryophyllus, Feuille de Clou de Girofle, Fleur de Clou de Girofle, Flores Caryophylli, Flores Caryophyllum, Gewurznelken Nagelein, Girofle, Giroflier, Huile de Clou de Girofle, Kreteks, Lavang, Lavanga, Oil of Clove, Syzygium aromaticum, Tige de Clou de Girofle.

Methodology

To learn more about how this article was written, please see the Natural Medicines Comprehensive Database methodology.

References

  1. Jahanshir M, Nobahar M, Ghorbani R, Malek F. Effect of clove mouthwash on the incidence of ventilator-associated pneumonia in intensive care unit patients: a comparative randomized triple-blind clinical trial. Clin Oral Investig 2023;27:3589-3600. View abstract.
  2. Mammen RR, Natinga Mulakal J, Mohanan R, Maliakel B, Illathu Madhavamenon K. Clove bud polyphenols alleviate alterations in inflammation and oxidative stress markers associated with binge drinking: a randomized double-blinded placebo-controlled crossover study. J Med Food 2018;21:1188-96. View abstract.
  3. Ibrahim IM, Abdel Kareem IM, Alghobashy MA. Evaluation of topical liposome incorporated clove oil in the treatment of idiopathic palmar hyperhidrosis: Single-blinded placebo-controlled study. J Cosmet Dermatol 2018;17:1084-9. View abstract.
  4. Mohan R, Jose S, Mulakkal J, Karpinsky-Semper D, Swick AG, Krishnakumar IM. Water-soluble polyphenol-rich clove extract lowers pre- and post-prandial blood glucose levels in healthy and prediabetic volunteers: an open label pilot study. BMC Complement Altern Med 2019;19:99. View abstract.
  5. Jiang Q, Wu Y, Zhang H, et al. Development of essential oils as skin permeation enhancers: penetration enhancement effect and mechanism of action. Pharmaceutical Biol. 2017;55:1592-1600. View abstract.
  6. Ibrahim IM, Elsaie ML, Almohsen AM, Mohey-Eddin MH. Effectiveness of topical clove oil on symptomatic treatment of chronic pruritus. J Cosmet Dermatol 2017;16:508-11. View abstract.
  7. Kim A, Farkas AN, Dewar SB, Abesamis MG. Early administration of N-acetylcysteine in the treatment of clove oil ingestion. J Pediatr Gastroenterol Nutr. 2018;67:e38-e39. View abstract.
  8. Machado M, Dinis AM, Salgueiro L, Custódio JB, Cavaleiro C, Sousa MC. Anti-Giardia activity of Syzygium aromaticum essential oil and eugenol: effects on growth, viability, adherence and ultrastructure. Exp Parasitol 2011;127:732-9. View abstract.
  9. Liu H, Schmitz JC, Wei J, et al. Clove extract inhibits tumor growth and promotes cell cycle arrest and apoptosis. Oncol Res 2014;21:247-59. View abstract.
  10. Kothiwale SV, Patwardhan V, Gandhi M, Sohoni R, Kumar A. A comparative study of antiplaque and antigingivitis effects of herbal mouthrise containing tea tree oil, clove, and basil with commercially available essential oil mouthrinse. J Indian Soc Periodontol 2014;18: 316-20. View abstract.
  11. Dwivedi V, Shrivastava R, Hussain S, Ganguly C, Bharadwaj M. Comparative anticancer potential of clove (Syzygium aromaticum)- an Indian spice- against cancer cell lines of various anatomical origin. Asian Pac J Cancer Prev 2011;12:1989-93. View abstract.
  12. Cortés-Rojas DF, de Souza CR, Oliveira WP. Clove (Syzygium aromaticum): a precious spice. Asian Pac J Trop Biomed 2014;4:90-6. View abstract.
  13. Yarnell E and Abascal K. Botanical medicines for headache. Alternative & Complementary Therapies (England) 2007;13:148-152.
  14. Hussein E, Ahu A, and Kadir T. Investigation of bacteremia after toothbrushing in orthodontic patients. Korean Journal of Orthodontics 2009;39:177-184.
  15. Kadey M. Lost in spice. Natural Health 2007;37:43-50.
  16. Kim, H. M., Lee, E. H., Hong, S. H., Song, H. J., Shin, M. K., Kim, S. H., and Shin, T. Y. Effect of Syzygium aromaticum extract on immediate hypersensitivity in rats. J Ethnopharmacol. 1998;60:125-131. View abstract.
  17. Smith-Palmer, A., Stewart, J., and Fyfe, L. Antimicrobial properties of plant essential oils and essences against five important food-borne pathogens. Lett Appl Microbiol. 1998;26:118-122. View abstract.
  18. Segura, J. J. and Jimenez-Rubio, A. Effect of eugenol on macrophage adhesion in vitro to plastic surfaces. Endod.Dent.Traumatol. 1998;14:72-74. View abstract.
  19. Kim, H. M., Lee, E. H., Kim, C. Y., Chung, J. G., Kim, S. H., Lim, J. P., and Shin, T. Y. Antianaphylactic properties of eugenol. Pharmacol Res 1997;36:475-480. View abstract.
  20. Natural compounds fight oral pathogens. J Am.Dent.Assoc. 1996;127:1582. View abstract.
  21. Schattner, P. and Randerson, D. Tiger Balm as a treatment of tension headache. A clinical trial in general practice. Aust.Fam.Physician 1996;25:216, 218, 220. View abstract.
  22. Srivastava, K. C. Antiplatelet principles from a food spice clove (Syzygium aromaticum L) [corrected]. Prostaglandins Leukot.Essent.Fatty Acids 1993;48:363-372. View abstract.
  23. Hartnoll, G., Moore, D., and Douek, D. Near fatal ingestion of oil of cloves. Arch.Dis Child 1993;69:392-393. View abstract.
  24. Saeed, S. A. and Gilani, A. H. Antithrombotic activity of clove oil. J Pak Med Assoc 1994;44:112-115. View abstract.
  25. Shapiro, S., Meier, A., and Guggenheim, B. The antimicrobial activity of essential oils and essential oil components towards oral bacteria. Oral Microbiol.Immunol. 1994;9:202-208. View abstract.
  26. Stojicevic, M., Dordevic, O., Kostic, L., Madanovic, N., and Karanovic, D. [Action of clove oil, eugenol, and zinc-oxide eugenol paste on the dental pulp within "in vitro" conditions]. Stomatol.Glas.Srb. 1980;27:85-89. View abstract.
  27. Isaacs, G. Permanent local anaesthesia and anhidrosis after clove oil spillage. Lancet 4-16-1983;1:882. View abstract.
  28. Hackett, P. H., Rodriguez, G., and Roach, R. C. Clove cigarettes and high-altitude pulmonary edema. JAMA 6-28-1985;253:3551-3552. View abstract.
  29. Fotos, P. G., Woolverton, C. J., Van Dyke, K., and Powell, R. L. Effects of eugenol on polymorphonuclear cell migration and chemiluminescence. J Dent.Res. 1987;66:774-777. View abstract.
  30. Buch, J. G., Dikshit, R. K., and Mansuri, S. M. Effect of certain volatile oils on ejaculated human spermatozoa. Indian J Med Res 1988;87:361-363. View abstract.
  31. Romaguera, C., Alomar, A., Camarasa, J. M., Garcia, Bravo B., Garcia, Perez A., Grimalt, F., Guerra, P., Lopez, Gorretcher B., Pascual, A. M., Miranda, A., and . Contact dermatitis in children. Contact Dermatitis 1985;12:283-284. View abstract.
  32. Mitchell, R. Treatment of fibrinolytic alveolitis by a collagen paste (Formula K). A preliminary report. Int J Oral Maxillofac.Surg. 1986;15:127-133. View abstract.
  33. Anonymous. Evaluation of the health hazard of clove cigarettes. Council on Scientific Affairs. JAMA 12-23-1988;260:3641-3644. View abstract.
  34. Azuma, Y., Ozasa, N., Ueda, Y., and Takagi, N. Pharmacological studies on the anti-inflammatory action of phenolic compounds. J Dent.Res. 1986;65:53-56. View abstract.
  35. Guidotti, T. L., Laing, L., and Prakash, U. B. Clove cigarettes. The basis for concern regarding health effects. West J Med 1989;151:220-228. View abstract.
  36. Saeki, Y., Ito, Y., Shibata, M., Sato, Y., Okuda, K., and Takazoe, I. Antimicrobial action of natural substances on oral bacteria. Bull.Tokyo Dent Coll. 1989;30:129-135. View abstract.
  37. Jorkjend, L. and Skoglund, L. A. Effect of non-eugenol- and eugenol-containing periodontal dressings on the incidence and severity of pain after periodontal soft tissue surgery. J Clin Periodontol. 1990;17:341-344. View abstract.
  38. Cisak, E., Wojcik-Fatla, A., Zajac, V., and Dutkiewicz, J. Repellents and acaricides as personal protection measures in the prevention of tick-borne diseases. Ann Agric.Environ.Med. 2012;19:625-630. View abstract.
  39. Revay, E. E., Junnila, A., Xue, R. D., Kline, D. L., Bernier, U. R., Kravchenko, V. D., Qualls, W. A., Ghattas, N., and Muller, G. C. Evaluation of commercial products for personal protection against mosquitoes. Acta Trop. 2013;125:226-230. View abstract.
  40. Dyrbye, B. A., Dubois, L., Vink, R., and Horn, J. A patient with clove oil intoxication. Anaesth.Intensive Care 2012;40:365-366. View abstract.
  41. Xing, F., Tan, Y., Yan, G. J., Zhang, J. J., Shi, Z. H., Tan, S. Z., Feng, N. P., and Liu, C. H. Effects of Chinese herbal cataplasm Xiaozhang Tie on cirrhotic ascites. J Ethnopharmacol. 1-31-2012;139:343-349. View abstract.
  42. Jayashankar, S., Panagoda, G. J., Amaratunga, E. A., Perera, K., and Rajapakse, P. S. A randomised double-blind placebo-controlled study on the effects of a herbal toothpaste on gingival bleeding, oral hygiene and microbial variables. Ceylon Med.J 2011;56:5-9. View abstract.
  43. Sosto, F. and Benvenuti, C. Controlled study on thymol + eugenol vaginal douche versus econazole in vaginal candidiasis and metronidazole in bacterial vaginosis. Arzneimittelforschung. 2011;61:126-131. View abstract.
  44. Srivastava, K. C. and Malhotra, N. Acetyl eugenol, a component of oil of cloves (Syzygium aromaticum L.) inhibits aggregation and alters arachidonic acid metabolism in human blood platelets. Prostaglandins Leukot.Essent.Fatty Acids 1991;42:73-81. View abstract.
  45. Burgoyne, C. C., Giglio, J. A., Reese, S. E., Sima, A. P., and Laskin, D. M. The efficacy of a topical anesthetic gel in the relief of pain associated with localized alveolar osteitis. J Oral Maxillofac.Surg. 2010;68:144-148. View abstract.
  46. Kumar, P., Ansari, S. H., and Ali, J. Herbal remedies for the treatment of periodontal disease--a patent review. Recent Pat Drug Deliv.Formul. 2009;3:221-228. View abstract.
  47. Mayaud, L., Carricajo, A., Zhiri, A., and Aubert, G. Comparison of bacteriostatic and bactericidal activity of 13 essential oils against strains with varying sensitivity to antibiotics. Lett.Appl.Microbiol. 2008;47:167-173. View abstract.
  48. Park, C. K., Kim, K., Jung, S. J., Kim, M. J., Ahn, D. K., Hong, S. D., Kim, J. S., and Oh, S. B. Molecular mechanism for local anesthetic action of eugenol in the rat trigeminal system. Pain 2009;144(1-2):84-94. View abstract.
  49. Rodrigues, T. G., Fernandes, A., Jr., Sousa, J. P., Bastos, J. K., and Sforcin, J. M. In vitro and in vivo effects of clove on pro-inflammatory cytokines production by macrophages. Nat.Prod.Res. 2009;23:319-326. View abstract.
  50. Scarparo, R. K., Grecca, F. S., and Fachin, E. V. Analysis of tissue reactions to methacrylate resin-based, epoxy resin-based, and zinc oxide-eugenol endodontic sealers. J Endod. 2009;35:229-232. View abstract.
  51. Fu, Y., Chen, L., Zu, Y., Liu, Z., Liu, X., Liu, Y., Yao, L., and Efferth, T. The antibacterial activity of clove essential oil against Propionibacterium acnes and its mechanism of action. Arch.Dermatol. 2009;145:86-88. View abstract.
  52. Agbaje, E. O. Gastrointestinal effects of Syzigium aromaticum (L) Merr. & Perry (Myrtaceae) in animal models. Nig.Q.J Hosp.Med 2008;18:137-141. View abstract.
  53. Mishra, R. K. and Singh, S. K. Safety assessment of Syzygium aromaticum flower bud (clove) extract with respect to testicular function in mice. Food Chem.Toxicol. 2008;46:3333-3338. View abstract.
  54. Morsy, M. A. and Fouad, A. A. Mechanisms of gastroprotective effect of eugenol in indomethacin-induced ulcer in rats. Phytother.Res. 2008;22:1361-1366. View abstract.
  55. Chung, G., Rhee, J. N., Jung, S. J., Kim, J. S., and Oh, S. B. Modulation of CaV2.3 calcium channel currents by eugenol. J Dent.Res. 2008;87:137-141. View abstract.
  56. Chen, D. C., Lee, Y. Y., Yeh, P. Y., Lin, J. C., Chen, Y. L., and Hung, S. L. Eugenol inhibited the antimicrobial functions of neutrophils. J Endod. 2008;34:176-180. View abstract.
  57. Pongprayoon, U., Baeckstrom, P., Jacobsson, U., Lindstrom, M., and Bohlin, L. Compounds inhibiting prostaglandin synthesis isolated from Ipomoea pes-caprae. Planta Med 1991;57:515-518. View abstract.
  58. Li, H. Y., Park, C. K., Jung, S. J., Choi, S. Y., Lee, S. J., Park, K., Kim, J. S., and Oh, S. B. Eugenol inhibits K+ currents in trigeminal ganglion neurons. J Dent.Res. 2007;86:898-902. View abstract.
  59. Quirce, S., Fernandez-Nieto, M., del, Pozo, V, Sastre, B., and Sastre, J. Occupational asthma and rhinitis caused by eugenol in a hairdresser. Allergy 2008;63:137-138. View abstract.
  60. Elwakeel, H. A., Moneim, H. A., Farid, M., and Gohar, A. A. Clove oil cream: a new effective treatment for chronic anal fissure. Colorectal Dis. 2007;9:549-552. View abstract.
  61. Fu, Y., Zu, Y., Chen, L., Shi, X., Wang, Z., Sun, S., and Efferth, T. Antimicrobial activity of clove and rosemary essential oils alone and in combination. Phytother.Res. 2007;21:989-994. View abstract.
  62. Lee, Y. Y., Hung, S. L., Pai, S. F., Lee, Y. H., and Yang, S. F. Eugenol suppressed the expression of lipopolysaccharide-induced proinflammatory mediators in human macrophages. J Endod. 2007;33:698-702. View abstract.
  63. Chaieb, K., Hajlaoui, H., Zmantar, T., Kahla-Nakbi, A. B., Rouabhia, M., Mahdouani, K., and Bakhrouf, A. The chemical composition and biological activity of clove essential oil, Eugenia caryophyllata (Syzigium aromaticum L. Myrtaceae): a short review. Phytother.Res. 2007;21:501-506. View abstract.
  64. Fabio, A., Cermelli, C., Fabio, G., Nicoletti, P., and Quaglio, P. Screening of the antibacterial effects of a variety of essential oils on microorganisms responsible for respiratory infections. Phytother.Res. 2007;21:374-377. View abstract.
  65. Rahim, Z. H. and Khan, H. B. Comparative studies on the effect of crude aqueous (CA) and solvent (CM) extracts of clove on the cariogenic properties of Streptococcus mutans. J Oral Sci 2006;48:117-123. View abstract.
  66. Park, C. K., Li, H. Y., Yeon, K. Y., Jung, S. J., Choi, S. Y., Lee, S. J., Lee, S., Park, K., Kim, J. S., and Oh, S. B. Eugenol inhibits sodium currents in dental afferent neurons. J Dent.Res. 2006;85:900-904. View abstract.
  67. Musenga, A., Ferranti, A., Saracino, M. A., Fanali, S., and Raggi, M. A. Simultaneous determination of aromatic and terpenic constituents of cloves by means of HPLC with diode array detection. J Sep.Sci 2006;29:1251-1258. View abstract.
  68. Lane, B. W., Ellenhorn, M. J., Hulbert, T. V., and McCarron, M. Clove oil ingestion in an infant. Hum.Exp Toxicol. 1991;10:291-294. View abstract.
  69. Alqareer, A., Alyahya, A., and Andersson, L. The effect of clove and benzocaine versus placebo as topical anesthetics. J Dent 2006;34:747-750. View abstract.
  70. Ozalp, N., Saroglu, I., and Sonmez, H. Evaluation of various root canal filling materials in primary molar pulpectomies: an in vivo study. Am J Dent. 2005;18:347-350. View abstract.
  71. Islam, S. N., Ferdous, A. J., Ahsan, M., and Faroque, A. B. Antibacterial activity of clove extracts against phagogenic strains including clinically resistant isolates of Shigella and Vibrio cholerae. Pak.J Pharm.Sci 1990;3:1-5. View abstract.
  72. Ahmad, N., Alam, M. K., Shehbaz, A., Khan, A., Mannan, A., Hakim, S. R., Bisht, D., and Owais, M. Antimicrobial activity of clove oil and its potential in the treatment of vaginal candidiasis. J Drug Target 2005;13:555-561. View abstract.
  73. Saltzman, B., Sigal, M., Clokie, C., Rukavina, J., Titley, K., and Kulkarni, G. V. Assessment of a novel alternative to conventional formocresol-zinc oxide eugenol pulpotomy for the treatment of pulpally involved human primary teeth: diode laser-mineral trioxide aggregate pulpotomy. Int J Paediatr.Dent. 2005;15:437-447. View abstract.
  74. Raghavenra, H., Diwakr, B. T., Lokesh, B. R., and Naidu, K. A. Eugenol--the active principle from cloves inhibits 5-lipoxygenase activity and leukotriene-C4 in human PMNL cells. Prostaglandins Leukot.Essent.Fatty Acids 2006;74:23-27. View abstract.
  75. Muniz, L. and Mathias, P. The influence of sodium hypochlorite and root canal sealers on post retention in different dentin regions. Oper.Dent. 2005;30:533-539. View abstract.
  76. Lee, M. H., Yeon, K. Y., Park, C. K., Li, H. Y., Fang, Z., Kim, M. S., Choi, S. Y., Lee, S. J., Lee, S., Park, K., Lee, J. H., Kim, J. S., and Oh, S. B. Eugenol inhibits calcium currents in dental afferent neurons. J Dent.Res. 2005;84:848-851. View abstract.
  77. Trongtokit, Y., Rongsriyam, Y., Komalamisra, N., and Apiwathnasorn, C. Comparative repellency of 38 essential oils against mosquito bites. Phytother Res 2005;19:303-309. View abstract.
  78. Janes, S. E., Price, C. S., and Thomas, D. Essential oil poisoning: N-acetylcysteine for eugenol-induced hepatic failure and analysis of a national database. Eur.J Pediatr 2005;164:520-522. View abstract.
  79. Park, B. S., Song, Y. S., Yee, S. B., Lee, B. G., Seo, S. Y., Park, Y. C., Kim, J. M., Kim, H. M., and Yoo, Y. H. Phospho-ser 15-p53 translocates into mitochondria and interacts with Bcl-2 and Bcl-xL in eugenol-induced apoptosis. Apoptosis. 2005;10:193-200. View abstract.
  80. Trongtokit, Y., Rongsriyam, Y., Komalamisra, N., Krisadaphong, P., and Apiwathnasorn, C. Laboratory and field trial of developing medicinal local Thai plant products against four species of mosquito vectors. Southeast Asian J Trop.Med Public Health 2004;35:325-333. View abstract.
  81. McDougal, R. A., Delano, E. O., Caplan, D., Sigurdsson, A., and Trope, M. Success of an alternative for interim management of irreversible pulpitis. J Am Dent.Assoc 2004;135:1707-1712. View abstract.
  82. Mortazavi, M. and Mesbahi, M. Comparison of zinc oxide and eugenol, and Vitapex for root canal treatment of necrotic primary teeth. Int J Paediatr.Dent. 2004;14:417-424. View abstract.
  83. Friedman, M., Henika, P. R., Levin, C. E., and Mandrell, R. E. Antibacterial activities of plant essential oils and their components against Escherichia coli O157:H7 and Salmonella enterica in apple juice. J Agric.Food Chem. 9-22-2004;52:6042-6048. View abstract.
  84. Jadhav, B. K., Khandelwal, K. R., Ketkar, A. R., and Pisal, S. S. Formulation and evaluation of mucoadhesive tablets containing eugenol for the treatment of periodontal diseases. Drug Dev.Ind.Pharm. 2004;30:195-203. View abstract.
  85. Eisen, J. S., Koren, G., Juurlink, D. N., and Ng, V. L. N-acetylcysteine for the treatment of clove oil-induced fulminant hepatic failure. J Toxicol.Clin Toxicol. 2004;42:89-92. View abstract.
  86. Zanata, R. L., Navarro, M. F., Barbosa, S. H., Lauris, J. R., and Franco, E. B. Clinical evaluation of three restorative materials applied in a minimal intervention caries treatment approach. J Public Health Dent. 2003;63:221-226. View abstract.
  87. Yang, B. H., Piao, Z. G., Kim, Y. B., Lee, C. H., Lee, J. K., Park, K., Kim, J. S., and Oh, S. B. Activation of vanilloid receptor 1 (VR1) by eugenol. J Dent.Res. 2003;82:781-785. View abstract.
  88. Brown, S. A., Biggerstaff, J., and Savidge, G. F. Disseminated intravascular coagulation and hepatocellular necrosis due to clove oil. Blood Coagul.Fibrinolysis 1992;3:665-668. View abstract.
  89. Kim, S. S., Oh, O. J., Min, H. Y., Park, E. J., Kim, Y., Park, H. J., Nam, Han Y., and Lee, S. K. Eugenol suppresses cyclooxygenase-2 expression in lipopolysaccharide-stimulated mouse macrophage RAW264.7 cells. Life Sci. 6-6-2003;73:337-348. View abstract.
  90. Bhalla, M. and Thami, G. P. Acute urticaria due to dental eugenol. Allergy 2003;58:158. View abstract.
  91. Huss, U., Ringbom, T., Perera, P., Bohlin, L., and Vasange, M. Screening of ubiquitous plant constituents for COX-2 inhibition with a scintillation proximity based assay. J Nat Prod. 2002;65:1517-1521. View abstract.
  92. Sarrami, N., Pemberton, M. N., Thornhill, M. H., and Theaker, E. D. Adverse reactions associated with the use of eugenol in dentistry. Br.Dent.J 9-14-2002;193:257-259. View abstract.
  93. Ghelardini, C., Galeotti, N., Di Cesare, Mannelli L., Mazzanti, G., and Bartolini, A. Local anaesthetic activity of beta-caryophyllene. Farmaco 2001;56(5-7):387-389. View abstract.
  94. Andersen, K. E., Johansen, J. D., Bruze, M., Frosch, P. J., Goossens, A., Lepoittevin, J. P., Rastogi, S., White, I., and Menne, T. The time-dose-response relationship for elicitation of contact dermatitis in isoeugenol allergic individuals. Toxicol.Appl.Pharmacol. 2-1-2001;170:166-171. View abstract.
  95. Sanchez-Perez, J. and Garcia-Diez, A. Occupational allergic contact dermatitis from eugenol, oil of cinnamon and oil of cloves in a physiotherapist. Contact Dermatitis 1999;41:346-347. View abstract.
  96. Barnard, D. R. Repellency of essential oils to mosquitoes (Diptera: Culicidae). J Med Entomol. 1999;36:625-629. View abstract.
  97. Pallares, D. E. Link between clove cigarettes and urticaria? Postgrad.Med 10-1-1999;106:153. View abstract.
  98. Arora, D. S. and Kaur, J. Antimicrobial activity of spices. Int.J Antimicrob.Agents 1999;12:257-262. View abstract.
  99. Soetiarto, F. The relationship between habitual clove cigarette smoking and a specific pattern of dental decay in male bus drivers in Jakarta, Indonesia. Caries Res 1999;33:248-250. View abstract.
  100. Singh, U. P., Singh, D. P., Maurya, S., Maheshwari, R., Singh, M., Dubey, R. S., and Singh, R. B. Investigation on the phenolics of some spices having pharmacotherapeuthic properties. J Herb.Pharmacother. 2004;4:27-42. View abstract.
  101. Nelson, R. L., Thomas, K., Morgan, J., and Jones, A. Non surgical therapy for anal fissure. Cochrane.Database.Syst.Rev. 2012;2:CD003431. View abstract.
  102. Prabuseenivasan, S., Jayakumar, M., and Ignacimuthu, S. In vitro antibacterial activity of some plant essential oils. BMC.Complement Altern.Med 2006;6:39. View abstract.
  103. Friedman, M., Henika, P. R., and Mandrell, R. E. Bactericidal activities of plant essential oils and some of their isolated constituents against Campylobacter jejuni, Escherichia coli, Listeria monocytogenes, and Salmonella enterica. J Food Prot. 2002;65:1545-1560. View abstract.
  104. Kaya GS, Yapici G, Savas Z, et al. Comparison of alvogyl, SaliCept patch, and low-level laser therapy in the management of alveolar osteitis.J Oral Maxillofac Surg. 2011;69:1571-7. View abstract.
  105. Kirsch CM, Yenokida GG, Jensen WA, et al. Non-cardiogenic pulmonary oedema due to the intravenous administration of clove oil. Thorax 1990;45:235-6. View abstract.
  106. Prasad RC, Herzog B, Boone B, et al. An extract of Syzygium aromaticum represses genes encoding hepatic gluconeogenic enzymes. J Ethnopharmacol 2005;96:295-301. View abstract.
  107. Malson JL, Lee EM, Murty R, et al. Clove cigarette smoking: biochemical, physiological, and subjective effects. Pharmacol Biochem Behav 2003;74:739-45. View abstract.
  108. Chen SJ, Wang MH, Chen IJ. Antiplatelet and calcium inhibitory properties of eugenol and sodium eugenol acetate. Gen Pharmacol 1996;27:629-33. View abstract.
  109. Hong CH, Hur SK, Oh OJ, et al. Evaluation of natural products on inhibition of inducible cyclooxygenase (COX-2) and nitric oxide synthase (iNOS) in cultured mouse macrophage cells. J Ethnopharmacol 2002;83:153-9. View abstract.
  110. Kanerva L, Estlander T, Jolanki R. Occupational allergic contact dermatitis from spices. Contact Dermatitis 1996;35:157-62. View abstract.
  111. Fetrow CW, Avila JR. Professional's Handbook of Complementary & Alternative Medicines. 1st ed. Springhouse, PA: Springhouse Corp., 1999.
  112. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  113. Choi HK, Jung GW, Moon KH, et al. Clinical study of SS-Cream in patients with lifelong premature ejaculation. Urology 2000;55:257-61. View abstract.
  114. Dorman HJ, Deans SG. Antimicrobial agents from plants: antibacterial activity of plant volatile oils. J Appl Microbiol 2000;88:308-16. View abstract.
  115. Zheng GQ, Kenney PM, Lam LK. Sesquiterpenes from clove (Eugenia caryophyllata) as potential anticarcinogenic agents. J Nat Prod 1992;55:999-1003. View abstract.
  116. Robbers JE, Tyler VE. Tyler's Herbs of Choice: The Therapeutic Use of Phytomedicinals. New York, NY: The Haworth Herbal Press, 1999.
  117. Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
  118. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
  119. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  120. Wichtl MW. Herbal Drugs and Phytopharmaceuticals. Ed. N.M. Bisset. Stuttgart: Medpharm GmbH Scientific Publishers, 1994.
  121. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  122. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  123. Tyler VE. Herbs of Choice. Binghamton, NY: Pharmaceutical Products Press, 1994.
Last reviewed - 03/28/2024