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Raspberry Ketone

What is it?

Raspberry ketone is a chemical that is found in red raspberries and other fruits. It's popular for obesity, but it's not clear if it helps.

It's believed that raspberry ketone might increase metabolism, increase how quickly the body burns fat, and reduce appetite. But evidence in humans is limited. Raspberry ketone is also found in kiwifruit, peaches, grapes, apples, other berries, rhubarb, and the bark of yew, maple, and pine trees.

People use raspberry ketone for obesity, hair loss, male pattern baldness, and other conditions, but there is no good scientific evidence to support these uses.

How effective is it?

There is interest in using raspberry ketone for a number of purposes, but there isn't enough reliable information to say whether it might be helpful.

Is it safe?

When taken by mouth: Raspberry ketone is commonly consumed in foods. When used as medicine, there isn't enough reliable information to know if raspberry ketone is safe. It is chemically related to a stimulant called synephrine, so it's possible that it might cause jitteriness, and increase blood pressure and heart rate.

Special precautions & warnings:

Pregnancy and breast-feeding: Raspberry ketone is commonly consumed in foods. But there isn't enough reliable information to know if raspberry ketone is safe to use as medicine when pregnant or breast-feeding. Stay on the safe side and avoid use.

Diabetes: Raspberry ketone might affect blood sugar levels. This might make it more difficult to control blood sugar in people taking medicines for diabetes.

Are there interactions with medications?

Be cautious with this combination.
Stimulant drugs
Stimulants, such as amphetamines and cocaine, speed up the nervous system. By speeding up the nervous system, stimulant medications can increase blood pressure and speed up the heartbeat. Raspberry ketone might also speed up the nervous system. Taking raspberry ketone along with stimulant drugs might cause serious problems including increased heart rate and high blood pressure.

Warfarin (Coumadin)
Warfarin is used to thin the blood and prevent blood clots. Raspberry ketone might reduce the effects of warfarin, which could increase the risk for blood clots. If you take warfarin, talk with your healthcare provider before taking raspberry ketone.

Are there interactions with herbs and supplements?

Herbs and supplements with stimulant properties
Raspberry ketone might have stimulant effects. Taking it with other supplements with similar effects might increase the chance of side effects, including rapid heartbeat and high blood pressure. Examples of supplements with this effect include 1,3-DMAA, bitter orange, caffeine-containing products, DMHA, and ephedra.

Are there interactions with foods?

There are no known interactions with foods.

How is it typically used?

There isn't enough reliable information to know what an appropriate dose of raspberry ketone might be. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult a healthcare professional before using.

Other names

4-(4-Hydroxyphenyl) butan-2-one, Cetona de Frambuesa, Cétone de Framboise, Frambinone, Raspberry Ketones, Red Raspberry Ketone, RK.


To learn more about how this article was written, please see the Natural Medicines Comprehensive Database methodology.


  1. Khattar A, Beeton I. Coronary vasospasm and raspberry ketones weight-loss supplement: Is there a connection? Anatol J Cardiol. 2020;24:205-208. View abstract.
  2. Li X, Wang Y, Yu C, et al. The signatures of liver metabolomics and gut microbiota in high-fat diet fed mice supplemented with rhododendrol. Food Funct 2022;13:13052-13063. View abstract.
  3. Abdelraheem KM, Younis NN, Shaheen MA, Elswefy SE, Ali SI. Raspberry ketone improves non-alcoholic fatty liver disease induced in rats by modulating sphingosine kinase/sphingosine-1-phosphate and toll-like receptor 4 pathways. J Pharm Pharmacol. 2023;75:985-994. View abstract.
  4. Ansari SA, Patel F, Ashouri D, Dhaliwal JSS, Desai A. Resistant Polymorphic Ventricular Tachycardia in a Patient Taking Raspberry Ketones Weight Loss Supplement. Cureus 2022;14:e33089. View abstract.
  5. Electronic Code of Federal Regulations. Title 21, Chapter 1, Subchapter B, Part 172: food additives permitted for direct addition to food for human consumption. Available at:
  6. Mir TM, Ma G, Ali Z, Khan IA, Ashfaq MK. Effect of Raspberry Ketone on Normal, Obese and Health-Compromised Obese Mice: A Preliminary Study. J Diet Suppl 2019 Oct 11:1-16. doi: 10.1080/19390211.2019.1674996. [Epub ahead of print]. View abstract.
  7. Kshatriya D, Li X, Giunta GM, et al. Phenolic-enriched raspberry fruit extract (Rubus idaeus) resulted in lower weight gain, increased ambulatory activity, and elevated hepatic lipoprotein lipase and heme oxygenase-1 expression in male mice fed a high-fat diet. Nutr Res 2019;68:19-33. doi: 10.1016/j.nutres.2019.05.005. View abstract.
  8. Ushiki, M., Ikemoto, T., and Sato, Y. Anti-obese activities of raspberry ketone. Aroma Research 2002;3:361.
  9. Sporstol, S. and Scheline, R. R. The metabolism of 4-(4-hydroxyphenyl)butan-2-one (raspberry ketone) in rats, guinea-pigs and rabbits. Xenobiotica 1982;12:249-257. View abstract.
  10. Lin, C. H., Ding, H. Y., Kuo, S. Y., Chin, L. W., Wu, J. Y., and Chang, T. S. Evaluation of in Vitro and in Vivo Depigmenting Activity of Raspberry Ketone from Rheum officinale. Int.J Mol.Sci. 2011;12:4819-4835. View abstract.
  11. Koeduka, T., Watanabe, B., Suzuki, S., Hiratake, J., Mano, J., and Yazaki, K. Characterization of raspberry ketone/zingerone synthase, catalyzing the alpha, beta-hydrogenation of phenylbutenones in raspberry fruits. Biochem.Biophys.Res Commun. 8-19-2011;412:104-108. View abstract.
  12. Jeong, J. B. and Jeong, H. J. Rheosmin, a naturally occurring phenolic compound inhibits LPS-induced iNOS and COX-2 expression in RAW264.7 cells by blocking NF-kappaB activation pathway. Food Chem.Toxicol. 2010;48(8-9):2148-2153. View abstract.
  13. Feron, G., Mauvais, G., Martin, F., Semon, E., and Blin-Perrin, C. Microbial production of 4-hydroxybenzylidene acetone, the direct precursor of raspberry ketone. Lett.Appl.Microbiol. 2007;45:29-35. View abstract.
  14. Garcia, C. V., Quek, S. Y., Stevenson, R. J., and Winz, R. A. Characterization of the bound volatile extract from baby kiwi (Actinidia arguta). J Agric.Food Chem. 8-10-2011;59:8358-8365. View abstract.
  15. Lopez, H. L., Ziegenfuss, T. N., Hofheins, J. E., Habowski, S. M., Arent, S. M., Weir, J. P., and Ferrando, A. A. Eight weeks of supplementation with a multi-ingredient weight loss product enhances body composition, reduces hip and waist girth, and increases energy levels in overweight men and women. J Int Soc Sports Nutr 2013;10:22. View abstract.
  16. Wang L, Meng X, Zhang F. Raspberry ketone protects rats fed high-fat diets against nonalcoholic steatohepatitis. J Med Food 2012;15:495-503. View abstract.
  17. Ushiki M, Ikemoto T, Sato Y. Anti-obese activities of raspberry ketone. Aroma Research 2002;3:361.
  18. Adverse Event Report. Raspberry Ketone. Natural MedWatch, September 18, 2011.
  19. Adverse Event Report. Raspberry Ketone. Natural MedWatch, April 27, 2012.
  20. Beekwilder J, van der Meer IM, Sibbesen O, et al. Microbial production of natural raspberry ketone. Biotechnol J 2007;2:1270-9. View abstract.
  21. Park KS. Raspberry ketone increases both lipolysis and fatty acid oxidation in 3T3-L1 adipocytes. Planta Med 2010;76:1654-8. View abstract.
  22. Harada N, Okajima K, Narimatsu N, et al. Effect of topical application of raspberry ketone on dermal production of insulin-like growth factor-I in mice and on hair growth and skin elasticity in humans. Growth Horm IGF Res 2008;18:335-44. View abstract.
  23. Ogawa Y, Akamatsu M, Hotta Y, et al. Effect of essential oils, such as raspberry ketone and its derivatives, on antiandrogenic activity based on in vitro reporter gene assay. Bioorg Med Chem Lett 2010;20:2111-4. View abstract.
  24. Morimoto C, Satoh Y, Hara M, et al. Anti-obese action of raspberry ketone. Life Sci 2005;77:194-204. . View abstract.
Last reviewed - 04/23/2024