URL of this page: https://medlineplus.gov/druginfo/natural/1185.html

Bacillus Coagulans

What is it?

Bacillus coagulans is a type of bacteria. It is used similarly to lactobacillus and other probiotics as "beneficial" bacteria.

People take Bacillus coagulans for irritable bowel syndrome (IBS), diarrhea, gas, airway infections, and many other conditions, but there is no good scientific evidence to support these uses.

Bacillus coagulans produces lactic acid and is often misclassified as lactobacillus. In fact, some commercial products containing Bacillus coagulans are marketed as Lactobacillus sporogenes. Unlike lactic acid bacteria such as lactobacillus or bifidobacteria, Bacillus coagulans forms spores. Spores are an important factor in telling Bacillus coagulans apart from other lactic acid bacteria.

How effective is it?

Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.

The effectiveness ratings for BACILLUS COAGULANS are as follows:

Possibly effective for...

  • A long-term disorder of the large intestines that causes stomach pain (irritable bowel syndrome or IBS). Clinical research shows that taking Bacillus coagulans daily for 56-90 days improves quality of life and decreases bloating, nausea, vomiting, abdominal pain, and the number of bowel movements in people with diarrhea-predominant IBS. Other clinical research shows that taking a specific combination product (Colinox, DMG Italia SRL) containing Bacillus coagulans and simethicone three times daily for 4 weeks improves bloating and discomfort in people with IBS.

Insufficient evidence to rate effectiveness for...

  • Liver scarring (cirrhosis). People with liver cirrhosis are more likely to develop an infection called spontaneous bacterial peritonitis, or SBP. Early research shows that taking a combination probiotic containing Bacillus coagulans and other bacteria three times daily, along with the drug norfloxacin, does not decrease a person's risk of developing SBP.
  • Constipation. Early research shows that taking Bacillus coagulans twice daily for 4 weeks can improve abdominal pain and discomfort in people who tend to have constipation.
  • Diarrhea. Early research in babies 6-24 months of age with diarrhea shows that taking Bacillus coagulans for up to 5 days doesn't alleviate diarrhea. But taking Bacillus coagulans does seem to improve diarrhea and stomach pain in adults.
  • Diarrhea caused by rotavirus. Early research in newborn babies shows that taking Bacillus coagulans daily for one year decreases the child's risk of developing rotavirus diarrhea.
  • Gas (flatulence). Early evidence in people who have gas after eating shows that taking a specific combination supplement containing Bacillus coagulans and a blend of enzymes daily for 4 weeks does not improve bloating or gas.
  • A digestive tract infection that can lead to ulcers (Helicobacter pylori or H. pylori). Early research shows that taking Bacillus coagulans helps treat stomach ulcers caused by H. pylori.
  • Indigestion (dyspepsia). Early research shows that taking Bacillus coagulans daily for 8 weeks can reduce symptoms of burping, belching, and sour taste. Other research shows that taking Bacillus coagulans twice daily for 4 weeks reduces stomach pain and bloating.
  • Excessive growth of bacteria in the small intestines. Early evidence shows that using a specific probiotic product (Lactol, Bioplus Life Sciences Pvt. Ltd.) containing Bacillus coagulans and fructo-oligosaccharides daily for 15 days of every month for 6 months might modestly decrease stomach pain and gas in people with potentially harmful bacteria in the intestine.
  • Rheumatoid arthritis (RA). Early research shows that taking Bacillus coagulans daily for 60 days in addition to normal treatment can reduce pain, but does not reduce the number of painful or swollen joints in people with RA. Bacillus coagulans also does not improve the ability to perform activities of daily living in people with RA.
  • A serious intestinal disease in premature infants (necrotizing enterocolitis or NEC). Babies that are born very early or with a very low weight are at a higher risk of developing a serious infection in the intestines called necrotizing enterocolitis. Early research in these babies shows that taking Bacillus coagulans daily until leaving the hospital does not prevent necrotizing enterocolitis or death. However, taking Bacillus coagulans does increase the number of babies that are able to tolerate food.
  • Build up of fat in the liver in people who drink little or no alcohol (nonalcoholic fatty liver disease or NAFLD).
  • Cancer prevention.
  • Infection of the gastrointestinal tract by a bacteria called Clostridium difficile.
  • Digestion problems.
  • High cholesterol.
  • A mild form of gum disease (gingivitis).
  • A digestive tract infection that can lead to ulcers (Helicobacter pylori or H. pylori).
  • Immune system strengthening.
  • Long-term swelling (inflammation) in the digestive tract (inflammatory bowel disease or IBD).
  • Infection of the airways.
  • Other conditions.
More evidence is needed to rate Bacillus coagulans for these uses.

Is it safe?

When taken by mouth: Bacillus coagulans is POSSIBLY SAFE when taken by mouth. Research shows that Bacillus coagulans in doses of 2 billion colony-forming units (CFUs) daily can be safely used for up to 3 months. Lower doses of Bacillus coagulans up to 100 million CFUs daily can be safely used for up to 1 year.

Special precautions & warnings:

Pregnancy and breast-feeding: There isn't enough reliable information about the safety of taking Bacillus coagulans if you are pregnant or breast feeding. Stay on the safe side and avoid use.

Children: Bacillus coagulans is POSSIBLY SAFE when taken by mouth in infants and children. Some research has shown that Bacillus coagulans up to 100 million colony-forming units daily can be safely used by infants for up to one year.

Are there interactions with medications?

Be cautious with this combination.
Antibiotic drugs
Antibiotics are used to reduce harmful bacteria in the body. Antibiotics can also reduce other bacteria in the body. Taking antibiotics along with Bacillus coagulans might reduce the potential benefits of Bacillus coagulans. To avoid this potential interaction, take Bacillus coagulans products at least 2 hours before or after antibiotics.

Are there interactions with herbs and supplements?

There are no known interactions with herbs and supplements.

Are there interactions with foods?

There are no known interactions with foods.

How is it typically used?

The following doses have been studied in scientific research:


  • For a long-term disorder of the large intestines that causes stomach pain (irritable bowel syndrome or IBS): Bacillus coagulans (Lactospore, Sabinsa Corporation) 2 billion colony-forming units daily for 90 days. Bacillus coagulans (GanedenBC30, Ganeden Biotech Inc.) 300 million to 2 billion colony-forming units daily for 8 weeks. Bacillus coagulans 2 billion colony-forming units three times daily for 80 days. Also, a specific combination product (Colinox, DMG Italia SRL) containing Bacillus coagulans and simethicone has been used after each meal three times daily for 4 weeks.

Other names

B. Coagulans, Bacillus Bacteria, Bacillus Probiotics, Bactéries Bacilles, Bactéries à Gram Positif Sporogènes, Bactérie Gram Positive en Forme de Bâtonnet, Gram Positive Spore-Forming Rod, L. Sporogenes, Lactobacillus Sporogenes, Lactobacillus Sporogènes, Probiotic, Probiotique, Spore-Forming Lactobacillus.


To learn more about how this article was written, please see the Natural Medicines Comprehensive Database methodology.


  1. Gupta AK, Maity C. Efficacy and safety of Bacillus coagulans LBSC in irritable bowel syndrome: A prospective, interventional, randomized, double-blind, placebo-controlled clinical study. Medicine (Baltimore). 2021;100:e23641. View abstract.
  2. Zhang J, Guo J, Li D, et al. The efficacy and safety of Clostridium butyricum and Bacillus coagulans in Helicobacter pylori eradication treatment: An open-label, single-arm pilot study. Medicine (Baltimore). 2020;99:e22976. View abstract.
  3. Kumar VV, Sudha KM, Bennur S, Dhanasekar KR. A prospective, randomized, open-label, placebo-controlled comparative study of Bacillus coagulans GBI-30,6086 with digestive enzymes in improving indigestion in geriatric population. J Family Med Prim Care. 2020;9:1108-1112. View abstract.
  4. Chang CW, Chen MJ, Shih SC, et al. Bacillus coagulans (PROBACI) in treating constipation-dominant functional bowel disorders. Medicine (Baltimore). 2020;99:e20098. View abstract.
  5. Soman RJ, Swamy MV. A prospective, randomized, double-blind, placebo-controlled, parallel-group study to evaluate the efficacy and safety of SNZ TriBac, a three-strain Bacillus probiotic blend for undiagnosed gastrointestinal discomfort. Int J Colorectal Dis. 2019;34:1971-1978. View abstract.
  6. Abhari K, Saadati S, Yari Z, et al. The effects of Bacillus coagulans supplementation in patients with non-alcoholic fatty liver disease: A randomized, placebo-controlled, clinical trial. Clin Nutr ESPEN. 2020;39:53-60. View abstract.
  7. Maity C, Gupta AK. A prospective, interventional, randomized, double-blind, placebo-controlled clinical study to evaluate the efficacy and safety of Bacillus coagulans LBSC in the treatment of acute diarrhea with abdominal discomfort. Eur J Clin Pharmacol. 2019;75:21-31. View abstract.
  8. Hun L. Bacillus coagulans significantly improved abdominal pain and bloating in patients with IBS. Postgrad Med 2009;121:119-24. View abstract.
  9. Yang OO, Kelesidis T, Cordova R, Khanlou H. Immunomodulation of antiretroviral drug-suppressed chronic HIV-1 infection in an oral probiotic double-blind placebo-controlled trial. AIDS Res Hum Retroviruses 2014;30:988-95. View abstract.
  10. Dutta P, Mitra U, Dutta S, et al. Randomised controlled clinical trial of Lactobacillus sporogenes (Bacillus coagulans), used as a probiotic in clinical practice, on acute watery diarrhea in children. Trop Med Int Health 2011;16:555-61. View abstract.
  11. Endres JR, Clewell A, Jade KA, et al. Safety assessment of a proprietary preparation of a novel probiotic, Bacillus coagulans, as a food ingredient. Food Chem Toxicol 2009;47:1231-8. View abstract.
  12. Kalman DS, Schwartz HI, Alvarez P, et al. A prospective, randomized, double-blind, placebo-controlled parallel-group dual site trial to evaluate the effects of a Bacillus coagulans-based product on functional intestinal gas symptoms. BMC Gastroenterol 2009;9:85. View abstract.
  13. Dolin BJ. Effects of a proprietary Bacillus coagulans preparation on symptoms of diarrhea-predominant irritable bowel syndrome. Methods Find Exp Clin Pharmacol 2009;31:655-9. View abstract.
  14. Mandel DR, Eichas K, Holmes J. Bacillus coagulans: a viable adjunct therapy for relieving symptoms of rheumatoid arthritis according to a randomized, controlled trial. BMC Complement Altern Med 2010;10:1. View abstract.
  15. Sari FN, Dizdar EA, Oguz S, et al. Oral probiotics: Lactobacillus sporogenes for prevention of necrotizing enterocolitis in very low-birth weight infants: a randomized, controlled trial. Eur J Clin Nutr 2011;65:434-9. View abstract.
  16. Riazi S, Wirawan RE, Badmaev V, Chikindas ML. Characterization of lactosporin, a novel antimicrobial protein produced by Bacillus coagulans ATCC 7050. J Appl Microbiol 2009;106:1370-7. View abstract.
  17. Pande C, Kumar A, Sarin SK. Addition of probiotics to norfloxacin does not improve efficacy in the prevention of spontaneous bacterial peritonitis: a double-blind placebo-controlled randomized-controlled trial. Eur J Gastroenterol Hepatol 2012;24:831-9. View abstract.
  18. Majeed M, Nagabhushanam K, Natarajan S, et al. Bacillus coagulans MTCC 5856 supplementation in the management of diarrhea predominant irritable bowel syndrome: a double blind randomized placebo controlled pilot clinical study. Nutr J 2016;15:21. View abstract.
  19. Chandra RK. Effect of Lactobacillus on the incidence and severity of acute rotavirus diarrhea in infants. A prospective placebo-controlled double-blind study. Nutr Res 2002;22:65-9.
  20. De Vecchi E, Drago L. Lactobacillus sporogenes or Bacillus coagulans: misidentification or mislabeling? Int J Probiotics Prebiotics 2006;1:3-10.
  21. Jurenka JS. Bacillus coagulans: Monograph. Altern Med Rev 2012;17:76-81. View abstract.
  22. Urgesi R, Casale C, Pistelli R, et al. A randomized double-blind placebo-controlled trial on efficacy and safety of association of simethicone and Bacillus coagulans (Colinox) in patients with irritable bowel syndrome. Eur Rev Med Pharmacol Sci 2014;18:1344-53. View abstract.
  23. Khalighi AR, Khalighi MR, Behdani R, et al. Evaluating the efficacy of probiotic on treatment in patients with small intestinal bacterial overgrowth (SIBO)--a pilot study. Indian J Med Res. 2014 N ov;140:604-8. View abstract.
  24. Czaczyk K, Tojanowska K, Mueller A. Antifungal activity of Bacillus coagulans against Fusarium sp. Acta Microbiol Pol 2002;51:275-83. View abstract.
  25. Donskey CJ, Hoyen CK, Das SM, et al. Effect of oral Bacillus coagulans administration on the density of vancomycin-resistant enterococci in the stool of colonized mice. Lett Appl Microbiol 2001;33:84-8. View abstract.
  26. Hyronimus B, Le Marrec C, Urdaci MC. Coagulin, a bacteriocin-like inhibitory subtances produced by Bacillus coagulans I4. J Appl Microbiol 1998;85:42-50. View abstract.
  27. Probiotics for antibiotic-associated diarrhea. Pharmacist's Letter / Prescriber's Letter 2000;16:160103.
  28. Duc LH, Hong HA, Barbosa TM, et al. Characterization of Bacillus probiotics available for human use. Appl Environ Microbiol 2004;70:2161-71. View abstract.
  29. Velraeds MM, van der Mei HC, Reid G, Busscher HJ. Inhibition of initial adhesion of uropathogenic Enterococcus faecalis by biosurfactants from Lactobacillus isolates. Appl Environ Microbiol 1996;62:1958-63. View abstract.
  30. McGroarty JA. Probiotic use of lactobacilli in the human female urogenital tract. FEMS Immunol Med Microbiol 1993;6:251-64. View abstract.
  31. Reid G, Bruce AW, Cook RL, et al. Effect on urogenital flora of antibiotic therapy for urinary tract infection. Scand J Infect Dis 1990;22:43-7. View abstract.
Last reviewed - 06/08/2021