Why is this medication prescribed?
Efavirenz is used along with other medications to treat human immunodeficiency virus (HIV) infection. Efavirenz is in a class of medications called non-nucleoside reverse transcriptase inhibitors (NNRTIs). It works by decreasing the amount of HIV in the blood. Although efavirenz does not cure HIV, it may decrease your chance of developing acquired immunodeficiency syndrome (AIDS) and HIV-related illnesses such as serious infections or cancer. Taking these medications along with practicing safer sex and making other life-style changes may decrease the risk of transmitting (spreading) the HIV virus to other people.
How should this medicine be used?
Efavirenz comes as a capsule and as a tablet to take by mouth. It is usually taken once a day with plenty of water on an empty stomach (at least 1 hour before or 2 hours after a meal). Take efavirenz at around the same time every day. Taking efavirenz at bedtime may make certain side effects less bothersome. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take efavirenz exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Swallow the tablets and capsules whole; do not split, chew, or crush them.
If you are not able to swallow the medication whole, mix the contents of the capsule with soft food to eat. To prepare each dose, open the capsule and sprinkle the contents onto 1 to 2 teaspoons (5 to 10 mL) oof soft food in a small container. Use soft foods such as applesauce, grape jelly, or yogurt. Be careful not to spill the contents of the capsule or spread it in the air. Mix the medicine with the soft food. The mixture should look grainy but should not be lumpy. Eat the mixture within 30 minutes of mixing. When finished, add another 2 teaspoons (10 mL) of soft food to the empty container, stir, and eat to be sure that you have received the full dose of medication. Do not eat again for the next 2 hours.
If efavirenz is being given to a baby who cannot eat solid foods, mix the contents of the capsule with 2 teaspoons (10 mL) of room temperature infant formula in a small container. Be careful not to spill the contents of the capsule, or spread it in the air. The mixture should look grainy but should not be lumpy. Syringe feed the mixture within 30 minutes of mixing. When finished, add an additional 2 teaspoons (10 mL) of infant formula to the empty container, stir, and syringe feed to the baby to be sure that you have given the full dose of medication. Do not give the medication to the baby in a bottle. Do not feed the baby again for the next 2 hours.
Efavirenz controls HIV infection, but does not cure it. Continue to take efavirenz even if you feel well. Do not stop taking efavirenz without talking to your doctor. When your supply of efavirenz starts to run low, get more from your doctor or pharmacist. If you miss doses or stop taking efavirenz, your condition may become more difficult to treat.
Other uses for this medicine
Efavirenz is also used with other medications to help prevent infection in healthcare workers or other people who were accidentally exposed to HIV. Talk to your doctor about the possible risks of using this medication for your condition.
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
What special precautions should I follow?
Before taking efavirenz,
- tell your doctor and pharmacist if you are allergic to efavirenz any other medications, or if you are allergic to any of the ingredients in efavirenz capsules or tablets. Ask your doctor or pharmacist for a list of the ingredients..
- you should know that efavirenz, is also available in combination with other medications with the brand name of Atripla. Tell your doctor if you are taking this medication to be sure you do not receive the same medication twice.
- tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: antidepressants, artemether and lumefantrine (Coartem), atazanavir (Reyataz), atorvastatin (Lipitor, in Caduet), atovaquone and proguanil, bupropion (Wellbutrin, Zyban, others, in Contrave), carbamazepine (Carbatrol, Epitol, Equetro, Tegretol, Teril), clarithromycin (Biaxin, in Prevpac), cyclosporine (Gengraf, Neoral, Sandimmune), delavirdine (Rescriptor), diltiazem (Cardizem CD, Cartia XT, Diltzac, Taztia XT), etravirine (Intelence), felodipine, fosamprenavir (Lexiva), itraconazole (Sporanox), indinavir (Crixivan), ketoconazole, lopinavir (in Kaletra), maraviroc (Selzentry), medications for anxiety, medications for mental illness, methadone (Dolophine, Methadose), nevirapine (Viramune), nicardipine (Cardene), nifedipine (Adalat, Afeditab, Procardia XL), phenobarbital, phenytoin (Dilantin, Phenytek), posaconazole (Noxafil), pravastatin (Pravachol), rifabutin (Mycobutin), rifampin (Rifadin, Rimactane, in Rifamate, Rifater), rilpivirine (Edurant, in Complera, Odefsey), ritonavir (Norvir, in Kaletra, Technivie, Viekira), saquinavir (Invirase), sedatives, sertraline (Zoloft), simeprevir (Olysio), simvastatin (Zocor, in Vytorin), sirolimus (Rapamune), sleeping pills, tacrolimus (Envarsus XR, Prograf), tranquilizers, verapamil (Calan, Covera, Verelan, in Tarka), voriconazole (Vfend), and warfarin (Coumadin, Jantoven), Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with efavirenz, or may increase the risk that you will develop an irregular heartbeat, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
- tell your doctor what herbal products you are taking, especially St. John's wort.
- tell your doctor if you drink or have ever drunk large amounts of alcohol; if you use or have ever used street drugs or have overused prescription medications; if you or anyone in your family has or has ever had a prolonged QT interval (a rare heart problem that may cause irregular heartbeat, fainting, or sudden death); or if you have or have ever had a low level of potassium or magnesium in your blood. seizures; depression or other mental illness; hepatitis B or C, or other liver problems; or heart disease.
- you should not become pregnant while taking efavirenz, and for 12 weeks after your final dose. You will have to have a negative pregnancy test before you begin taking this medication and use effective birth control during your treatment and for 12 weeks after your treatment is completed. Efavirenz may interfere with the action of hormonal contraceptives (birth control pills, patches, rings, implants, or injections, so you should not use these as your only method of birth control during your treatment. You must use a barrier method of birth control (device that blocks sperm from entering the uterus such as a condom or a diaphragm) along with any other method of birth control you have chosen. Ask your doctor to help you choose a method of birth control that will work for you. If you become pregnant while taking efavirenz, call your doctor. Efavirenz may harm the fetus.
- you should not breastfeed if you are infected with HIV or are taking efavirenz.
- you should know that efavirenz may make you drowsy, dizzy, or unable to concentrate. Do not drive a car or operate machinery until you know how this medication affects you.
- ask your doctor about the safe use of alcoholic beverages while you are taking efavirenz. Alcohol can make the side effects from efavirenz worse.
- you should know that while you are taking medications to treat HIV infection, your immune system may get stronger and begin to fight other infections that were already in your body or cause other conditions to occur. This may cause you to develop symptoms of those infections or conditions. If you have new or worsening symptoms during your treatment with efavirenz be sure to tell your doctor.
- you should know that your body fat may increase or move to different areas of your body such as your breasts and upper back, neck (''buffalo hump''), and around your stomach.You may notice a loss of body fat from your face, legs, and arms.
- you should know that efavirenz may cause changes in your thoughts, behavior, or mental health. Call your doctor immediately if you develop any of the following symptoms while you are taking efavirenz: depression, thinking about killing yourself or planning or trying to do so, angry or aggressive behavior, hallucinations (seeing things or hearing voices that do not exist), loss of touch with reality, or other strange thoughts. Be sure your family knows which symptoms may be serious so that they can call your doctor if you are unable to seek treatment on your own.
What special dietary instructions should I follow?
Talk to your doctor about eating grapefruit and drinking grapefruit juice while taking this medication.
What should I do if I forget a dose?
Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
What side effects can this medication cause?
Efavirenz may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- stomach pain
- feeling anxious, nervous, or agitated
- abnormally happy mood
- difficulty falling asleep or staying asleep
- unusual dreams
Some side effects can be serious. If you experience any of the following symptoms or those mentioned in the SPECIAL PRECAUTIONS section, call your doctor immediately:
- sore throat, cough, fever, chills, or other signs of infection
- peeling, blistering, or shedding skin
- mouth sores
- red or swollen eyes ("pink eye")
- swelling of your face
- irregular heartbeat
- extreme tiredness
- lack of energy
- loss of appetite
- pain in the upper right part of the stomach
- unusual bleeding or bruising
- yellowing of the skin or eyes
- flu-like symptoms
Efavirenz may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).
What should I know about storage and disposal of this medication?
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).
Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.
In case of emergency/overdose
In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
Symptoms of overdose may include the following:
- movements of your body that you cannot control
- difficulty concentrating
- difficulty falling asleep or staying asleep
- unusual dreams
- hallucinations (seeing things or hearing voices that do not exist)
- abnormally happy mood
- strange thoughts
What other information should I know?
Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your body's response to efavirenz.
Before having any laboratory test, tell your doctor and the laboratory personnel that you are taking efavirenz.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.