Tenecteplase Injection

Tenecteplase comes as a powder to mix with liquid to inject intravenously (into a vein) by a healthcare provider. It is usually given as a single dose as soon as possible after the symptoms of a heart attack begin.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking tenecteplase,

• tell your doctor and pharmacist if you are allergic to tenecteplase, any other medications, or any of the ingredients in tenecteplase injection. Ask your pharmacist for a list of the ingredients.
• tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take when receiving tenecteplase. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
• tell your doctor if you if you have had a stroke, a serious head injury, or surgery on your spine or brain in the last two months, or if you have problems in your brain such as bleeding, a tumor, arteriovenous malformation (AVM), or aneurysm (weakening of a blood vessel wall). Also tell your doctor if you have very high blood pressure that is not controlled by medications or any condition that may cause an increased risk of bleeding or bruising. Your doctor will probably not give you tenecteplase.
• tell your doctor if you have or have ever had heart valve problems or atrial fibrillation (Afib; a type of irregular heartbeat).
• tell your doctor if you are pregnant or are breast-feeding.

Unless your doctor tells you otherwise, continue your normal diet.

Tenecteplase may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• bleeding

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:

• itching, rash, hives
• swelling of face, eyelids, lips, mouth, tongue or throat
• trouble breathing, throat or chest tightness, feeling faint
• changes in heartbeat
• vomiting blood, blood in the urine or stool
• severe headache, nausea, vomiting
• change in consciousness or wakefulness
• weakness or numbness in face, arm or leg (usually on one side)
• loss of vision
• seizures

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (https://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep all appointments with your doctor and the laboratory. Your doctor will/may order certain lab tests to check your body's response to tenecteplase.

Before having any laboratory test, tell your doctor and the laboratory personnel that you are taking tenecteplase.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.