Arimoclomol

Arimoclomol is used in combination with miglustat to treat neurologic symptoms in adults and children 2 years of age and older who have Niemann-Pick disease type C (NPC; an inherited disease in which a certain fatty substance is not broken down and used normally in the body and instead builds up in some organs and can cause nerve and brain problems). Arimoclomol is in a class of medications called heat shock protein activators. It is not known exactly how arimoclomol works to treat neurologic symptoms in patients with Niemann-Pick disease type C.

Arimoclomol comes as a capsule to take by mouth. It is usually taken with or without food three times a day. Take arimoclomol at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take arimoclomol exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the capsules whole; do not chew or crush them.

If you are unable to swallow capsules whole, you may open the capsules and sprinkle the contents over one tablespoonful (15 mL) of water, apple juice, or a soft food such as applesauce, pudding, or yogurt in a small cup. Stir the mixture with a spoon for 15 seconds and swallow the mixture immediately. Do not store the mixture for future use.

If you have a nasogastric (NG) tube, your doctor or pharmacist will explain how to prepare arimoclomol to give through an NG tube.

Arimoclomol controls Niemann-Pick disease but does not cure it. Continue to take arimoclomol even if you feel well. Do not stop taking arimoclomol without talking to your doctor.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking arimoclomol,

• tell your doctor and pharmacist if you are allergic to arimoclomol, any other medications, or any of the ingredients in arimoclomol capsules. Ask your pharmacist for a list of the ingredients.
• tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take while taking arimoclomol. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
• tell your doctor if you have or have ever had kidney disease.
• tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. Your doctor may tell you to use birth control to prevent pregnancy while you are taking arimoclomol. If you become pregnant while taking arimoclomol, call your doctor. Arimoclomol may harm the fetus.

  You should know that arimoclomol may decrease fertility in men and women. Talk to your doctor about the risks of taking arimoclomol.

Unless your doctor tells you otherwise, continue your normal diet.

Skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

Arimoclomol may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• diarrhea
• weight loss
• decreased appetite
• nasal congestion, runny nose, sneezing, sore or scratchy throat, cough, or fever
• headache
• uncontrollable shaking of a part of the body

Some side effects can be serious. If you experience any of these symptoms, stop taking arimoclomol and call your doctor immediately or get emergency medical treatment:

• hives; rash; itching; swelling of the face, eyes, mouth, throat, tongue, or lips; difficulty breathing or swallowing; dizziness
• seizure

Arimoclomol may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (https://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from light, excess heat and moisture (not in the bathroom).

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Keep all appointments with your doctor.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

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