Recombinant Zoster (Shingles) Vaccine (RZV)

Recombinant shingles vaccine provides strong protection against shingles. By preventing shingles, recombinant shingles vaccine also protects against PHN.

Recombinant shingles vaccine is the preferred vaccine for the prevention of shingles. However, a different vaccine, live shingles vaccine, may be used in some circumstances.

The recombinant shingles vaccine is recommended for adults 50 years and older without serious immune problems. It is given as a two-dose series.

This vaccine is also recommended for people who have already gotten another type of shingles vaccine, the live shingles vaccine. There is no live virus in this vaccine.

Shingles vaccine may be given at the same time as other vaccines.

Tell your vaccine provider if the person getting the vaccine:

• Has had an allergic reaction after a previous dose of recombinant shingles vaccine, or has any severe, life-threatening allergies.
• Is pregnant or breastfeeding.
• Is currently experiencing an episode of shingles.

In some cases, your health care provider may decide to postpone shingles vaccination to a future visit.

People with minor illnesses, such as a cold, may be vaccinated. People who are moderately or severely ill should usually wait until they recover before getting recombinant shingles vaccine.

Your health care provider can give you more information.

• A sore arm with mild or moderate pain is very common after recombinant shingles vaccine, affecting about 80% of vaccinated people. Redness and swelling can also happen at the site of the injection.
• Tiredness, muscle pain, headache, shivering, fever, stomach pain, and nausea happen after vaccination in more than half of people who receive recombinant shingles vaccine.

In clinical trials, about 1 out of 6 people who got recombinant zoster vaccine experienced side effects that prevented them from doing regular activities. Symptoms usually went away on their own in 2 to 3 days.

You should still get the second dose of recombinant zoster vaccine even if you had one of these reactions after the first dose.

People sometimes faint after medical procedures, including vaccination. Tell your provider if you feel dizzy or have vision changes or ringing in the ears.

As with any medicine, there is a very remote chance of a vaccine causing a severe allergic reaction, other serious injury, or death.

An allergic reaction could occur after the vaccinated person leaves the clinic. If you see signs of a severe allergic reaction (hives, swelling of the face and throat, difficulty breathing, a fast heartbeat, dizziness, or weakness), call 9-1-1 and get the person to the nearest hospital.

For other signs that concern you, call your health care provider.

Adverse reactions should be reported to the Vaccine Adverse Event Reporting System (VAERS). Your health care provider will usually file this report, or you can do it yourself. Visit the VAERS website at https://www.vaers.hhs.gov or call 1-800-822-7967 . VAERS is only for reporting reactions, and VAERS staff do not give medical advice.

• Ask your healthcare provider.
• Call your local or state health department.
• Contact the Centers for Disease Control and Prevention (CDC):
• Call 1-800-232-4636 (1-800-CDC-INFO) or visit the CDC's website at https://www.cdc.gov/vaccines