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Atezolizumab Injection

pronounced as (a'' te zoe liz' ue mab)

Why is this medication prescribed?

Atezolizumab injection is used to treat urothelial cancer (cancer of the lining of the bladder and other parts of the urinary tract) that has spread and can not be removed by surgery, and has worsened after treatment with other chemotherapy medications. Atezolizumab injection is in a class of medications called monoclonal antibodies. It works by blocking the action of a certain protein in cancer cells. This helps the person's immune system to fight against the cancer cells, and helps to slow tumor growth.

How should this medicine be used?

Atezolizumab injection comes as liquid to be injected into a vein over 30 - 60 minutes by a doctor or nurse in a hospital or medical facility. It is usually injected once every 3 weeks. The length of your treatment depends on how well your body responds to the medication and the side effects that you experience.

Atezolizumab injection may cause serious reactions during the infusion of the medication. A doctor or nurse will monitor you carefully while you are receiving the medication. If you experience any of the following symptoms, tell your doctor immediately: flushing, fever, chills, shaking, dizziness, feeling faint, shortness of breath, difficulty breathing, itching, rash, back or neck pain, or swelling of the face.

Your doctor may need to slow down your infusion, delay or stop your treatment, or treat you with other medications if you experience certain side effects. Be sure to tell your doctor how you are feeling during your treatment with atezolizumab.

Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with atezolizumab injection and each time you receive the medication. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide.

Other uses for this medicine

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before taking atezolizumab injection,

  • tell your doctor and pharmacist if you are allergic to atezolizumab, any other medications, or any of the ingredients in atezolizumab injection. Ask your pharmacist or check the Medication Guide for a list of the ingredients.
  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • tell your doctor if you are being treated for an infection. Also tell your doctor if you have or have ever had an organ transplant; lung or breathing problems; disease that affects your nervous system such as myasthenia gravis (a disorder of the nervous system that causes muscle weakness) or Guillain-Barre syndrome (weakness, tingling, and possible paralysis due to sudden nerve damage); autoimmune disease (condition in which the immune system attacks a healthy part of the body) such as Crohn's disease (condition in which the immune system attacks the lining of the digestive tract causing pain, diarrhea, weight loss, and fever), ulcerative colitis (condition that causes swelling and sores in the lining of the colon [large intestine] and rectum) or lupus (condition in which the immune system attacks many tissues and organs including the skin, joints, blood, and kidneys); or liver disease.
  • tell your doctor if you are pregnant, or plan to become pregnant. You should not become pregnant during your treatment and for 5 months after your last dose. Talk to your doctor about birth control methods that you can use during your treatment. If you become pregnant while taking atezolizumab injection, call your doctor immediately.
  • tell your doctor if you are breast-feeding. Your doctor may tell you not to breast-feed during your treatment and for 5 months after your last dose.

What special dietary instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What side effects can this medication cause?

Atezolizumab injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • back, neck, or joint pain
  • rash
  • itching
  • pale skin
  • feeling hot or cold
  • swelling of arms
  • loss of appetite
  • constipation
  • hair loss
  • deepening of voice or hoarseness
  • weight gain or loss

Some side effects can be serious. If you experience any of these symptoms call your doctor immediately or get emergency medical treatment:

  • diarrhea
  • stomach pain
  • stomach bloating or swelling
  • severe nausea or vomiting
  • bloody or black tarry stools
  • fever
  • decreased urination
  • frequent, urgent, or painful urination
  • difficulty urinating
  • pink, red, or dark brown urine
  • swelling in your legs, ankles, or feet
  • warm, red, swollen, or tender leg
  • new or worsening cough
  • coughing up blood
  • shortness or breath
  • chest pain
  • yellowing of the skin or eyes
  • bleeding or bruising easily
  • extreme tiredness or drowsiness
  • headaches that won't go away or unusual headaches
  • neck stiffness
  • sensitivity to light
  • numbness or tingling in your hands, feet, arms, or legs
  • muscle weakness
  • problems with your vision
  • eye pain or redness
  • dizziness or feeling faint
  • feeling more hungry or thirsty than usual
  • changes in mood or behavior (decreased sex drive, irritability, confusion, or forgetfulness)
  • sore throat, chills, flu like symptoms, or other signs of infection
  • breath that smells fruity
  • slowed, fast or irregular heartbeat

Atezolizumab injection may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

In case of emergency/overdose

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

What other information should I know?

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests before and during your treatment with atezolizumab injection to check your body's response to the medication.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Brand names

  • Tecentriq®
Last Revised - 08/15/2016