Aflibercept Injection

Aflibercept injection, aflibercept-yszy injection, and aflibercept-jbvf injection are biologic medications (medications made from living organisms). Biosimilar aflibercept-yszy injection and aflibercept-jbvf injection are highly similar to aflibercept injection and work the same way as aflibercept injection in the body. Therefore, the term aflibercept injection products will be used to represent these medications in this discussion.

Aflibercept injection products are used to treat wet age-related macular degeneration (AMD; an ongoing disease of the eye that causes loss of the ability to see straight ahead and may make it more difficult to read, drive, or perform other daily activities), diabetic macular edema (an eye disease caused by diabetes that can lead to vision loss), and diabetic retinopathy (damage to the eyes caused by diabetes). Aflibercept injectionproducts are also used to treat macular edema after retinal vein occlusion (an eye disease caused by blockage of blood flow from the eye that leads to blurry vision and vision loss). Aflibercept injection is also used to treat retinopathy of prematurity (ROP; an eye disease that occurs in premature infants that can lead to vision loss and blindness). Aflibercept injection products are in a class of medications called vascular endothelial growth factor-A (VEGF-A) and placental growth factor (PlGF) antagonists. They work by stopping abnormal blood vessel growth and leakage in the eye(s) that may cause vision loss in people with certain eye conditions.

Aflibercept injection products comes as a solution (liquid) to be injected into the eye by a doctor. It is usually given in a doctor's office or healthcare facility. Your doctor will give you injections on a schedule that is best for you and your condition.

Before you receive an aflibercept injection product, your doctor will clean your eye to prevent infection and numb your eye to reduce discomfort during the injection. After your injection, your doctor will need to examine your eyes before you leave the office.

Aflibercept injection products control certain eye conditions, but do not cure them. Your doctor will watch you carefully to see how well aflibercept injection products work for you. Talk to your doctor about how long you should continue treatment with an aflibercept injection product.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before receiving aflibercept injection,

• tell your doctor and pharmacist if you are allergic to aflibercept, any other medications, or any of the ingredients in aflibercept injection products. Ask your pharmacist for a list of the ingredients.
• tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take.
• tell your doctor if you have an infection or swelling in or around the eye. Your doctor will probably tell you that you should not receive aflibercept injection.
• tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. You should not become pregnant right before starting your treatment and during your treatment, and for 3 to 4 months after your last injection with an aflibercept injection product. Use effective birth control before and during your treatment, and for 3 to 4 months after your final dose. Talk to your doctor about how long you should use birth control after your treatment with an aflibercept injection product. If you become pregnant while receiving an aflibercept injection product, call your doctor.
• you should know that aflibercept injection products may cause vision problems shortly after you receive the injection. Do not drive a car or operate machinery until your vision is back to normal.

Unless your doctor tells you otherwise, continue your normal diet.

If you miss an appointment to receive an aflibercept injection product, call your doctor as soon as possible.

Aflibercept injection products may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• feeling that something is in your eye
• teary eyes

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:

• eye redness or pain
• eye sensitivity to light
• blurred vision
• decrease or changes in vision
• bleeding in or around the eye
• seeing ''floaters'' or small specks
• injection site pain
• seeing flashes of lights
• chest pain
• shortness of breath
• sweating
• slow or difficult speech
• dizziness or faintness
• weakness or numbness of an arm or leg
• rash
• itching
• hives
• difficulty breathing or swallowing

Aflibercept injection products may cause other side effects. Call your doctor if you have any unusual problems while receiving this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (https://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Keep all appointments with your doctor. Your doctor will monitor your response to aflibercept injection products.

Ask your pharmacist any questions you have about aflibercept injection products.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

• Eylea^® (aflibercept)
• Eylea^® HD (aflibercept)
• Opuviz^® (aflibercept-yszy)
• Yesafili^® (aflibercept-jbvf)