Triptorelin Injection

Triptorelin injection is used to treat certain types of prostate cancer. It is also used to treat central precocious puberty (CPP; a condition causing children to enter puberty too soon, resulting in faster than normal bone growth and development of sexual characteristics). Triptorelin injection is in a class of medications called gonadotropin-releasing hormone (GnRH) agonists. It works by decreasing the amount of certain hormones in the body.

Triptorelin injection comes as an extended-release (long-acting) suspension to be injected into a muscle by a doctor or nurse in a medical office or clinic. Your doctor will tell you how often you will receive triptorelin injection.

Triptorelin may cause an increase in certain hormones in the first few weeks after injection. Your doctor will monitor you carefully for any new or worsening symptoms during this time.

Triptorelin may cause changes that lead to long-term conditions like diabetes, hyperlipidemia and, non-alcoholic liver disease. Your doctor will monitor your symptoms and labs during treatment for the development of any of these conditions. Discuss with your doctor any concerns you have about the long-term effects of using triptorelin.

Ask your doctor or pharmacist for a copy of the manufacturer's information for the patient.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before receiving triptorelin injection,

• tell your doctor or pharmacist if you are allergic to this medication, any part of this medication, or any other medications, foods or substances. Tell your doctor or pharmacist about the allergy and what symptoms you had.
• tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take.
• tell your doctor if you or anyone in your family has ever had long QT syndrome (condition that increases the risk of developing an irregular heartbeat that may cause fainting or sudden death). Also tell your doctor if you have or have ever had diabetes; cancer that has spread to the spine (backbone); urinary obstruction (blockage that causes difficulty urinating), a low level of potassium, calcium, or magnesium in your blood, a heart attack; heart failure; a mental illness; seizures; a stroke; a brain tumor; skin problems; or heart, kidney, or liver disease.
• you should know that triptorelin is not to be used in women who are pregnant or who can become pregnant. Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you think you have become pregnant while using triptorelin injection, call your doctor immediately. Triptorelin injection can harm the fetus.
• you should know that triptorelin injection may impair fertility in men.

Unless your doctor tells you otherwise, continue your normal diet.

If you miss an appointment to receive triptorelin injection, call your healthcare provider right away to reschedule your appointment.

Triptorelin injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• headache
• heartburn
• constipation
• hot flashes (a sudden wave of mild or intense body heat), sweating, or clamminess
• vaginal (menstrual) bleeding
• decreased sexual ability or desire
• mood changes such as crying, irritability, impatience, anger, and aggression
• leg or joint pain
• breast pain
• depression
• pain, itching, swelling, or redness at the place where injection was given
• difficulty falling asleep or staying asleep
• cough, runny nose, sore throat, or other signs of infection

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:

• hives rash; itching; difficulty breathing or swallowing; hoarseness; or swelling of the face, eyes, mouth, throat, tongue, or lips
• seizures
• chest pain; shortness of breath; rapid or irregular heartbeat; or pain in the arms, back, neck, or jaw
• slow, slurred, or difficult speech; dizziness or fainting; weakness or numbness on one side of your body; or sudden severe headache
• not able to move legs
• bone pain
• painful or difficult urination or blood in urine
• extreme thirst, weakness, blurred vision, dry mouth, or frequent urination
• nausea, vomiting, breath that smells fruity, confusion, or decreased consciousness
• dry, itchy, blistering, or peeling skin; rash; acne; redness or swelling of your face, hands or soles of your feet; mouth sores or blisters; muscle or joint aches; swollen glands; fever; or flu-like symptoms

In children receiving triptorelin injection for central precocious puberty, new or worsening symptoms of sexual development may occur during the first few weeks of treatment. In girls, the onset of menstruation or spotting (light vaginal bleeding) may occur during the first two months of this treatment. If bleeding continues beyond the second month, call your doctor.

Triptorelin injection may cause other side effects. Call your doctor if you have any unusual problems while using this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (https://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests and take certain body measurements to check your body's response to triptorelin injection. Your blood sugar and glycosylated hemoglobin (HbA1c) should be checked regularly.

Before having any laboratory test, tell your doctor and the laboratory personnel that you are receiving triptorelin injection.

Ask your pharmacist any questions you have about triptorelin injection.

Keep a written list of all of the prescription and nonprescription (over-the-counter) medicines, vitamins, minerals, and dietary supplements you are taking. Bring this list with you each time you visit a doctor or if you are admitted to the hospital. You should carry the list with you in case of emergencies.

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