An endometrial biopsy is a procedure in which a tissue sample is obtained from the endometrium (the inside lining of the uterus) and is then observed under a microscope. The tissue is thoroughly examined for any cell abnormalities or cancer. The test also helps determine the cause of abnormal menstrual periods, and can be used to screen for endometrial cancer. The test is sometimes used as part of the diagnostic work-up of women who have been unable to become pregnant.
Review Date 7/17/2017
Updated by: Cynthia D. White, MD, Fellow American College of Obstetricians and Gynecologists, Group Health Cooperative, Bellevue, WA. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.