Testicular biopsy is a procedure in which a small portion of testicle is removed for examination. The biopsy is performed by creating a small incision in the skin of the scrotum. A small piece of the testicle tissue is removed through the incision by snipping the sample off with small scissors. The test is usually performed when a semen analysis suggests that there is abnormal sperm, and other tests have not determined the cause. It may also be performed when testicular self-examination has revealed a lump.
Review Date 1/10/2021
Updated by: Kelly L. Stratton, MD, FACS, Associate Professor, Department of Urology, University of Oklahoma Health Sciences Center, Oklahoma City, OK. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.