Parasites are deposited in the skin by the bite of a sand-fly. These parasites (leishmania) produce a local sore at the site of the bite and migrate throughout the body, causing tissue destruction at distant sites.
Review Date 8/25/2019
Updated by: Jatin M. Vyas, MD, PhD, Assistant Professor in Medicine, Harvard Medical School; Assistant in Medicine, Division of Infectious Disease, Department of Medicine, Massachusetts General Hospital, Boston, MA. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.