Periventricular leukomalacia (PVL) is a type of brain injury. PVL actually represent small "holes" in the brain due to the death of small areas of brain tissue around the normal fluid-filled cavities of the brain. PVL is frequently associated with the development of neurological and developmental problems in growing babies, usually during the first to second year of life.
Review Date 11/9/2021
Updated by: Kimberly G. Lee, MD, MSc, IBCLC, Clinical Professor of Pediatrics, Division of Neonatology, Medical University of South Carolina, Charleston, SC. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.