The most common early sign of lyme disease is the appearance of a rash on the skin that looks like a "bull's eye". The rash begins as a reddened area near the area of the tick bite. As the rash gets bigger, it clears in the center and develops a red ring around the outer perimeter. Other symptoms include muscle or joint aches, stiff neck, headache, weakness, fever, swollen lymph nodes and other flu-like symptoms.
Update Date 1/1/2013
Updated by: Jacob L. Heller, MD, MHA, Emergency Medicine, Virginia Mason Medical Center, Seattle, WA. Also reviewed by A.D.A.M. Health Solutions, Ebix, Inc., Editorial Team: David Zieve, MD, MHA, Bethanne Black, Stephanie Slon, and Nissi Wang.