The fat layer of skin is located in the subcutaneous layer of tissue called the hypodermis. The thickness of the fat layer, which varies greatly from one person to another, depends on the size and number of fat cells.
Review Date 11/4/2020
Updated by: Elika Hoss, MD, Senior Associate Consultant, Mayo Clinic, Scottsdale, AZ. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.