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Fifth disease

Fifth disease

Overview

Fifth disease is an acute viral disease characterized by mild symptoms and a blotchy rash beginning on the cheeks and spreading to the extremities.

Review Date 7/1/2025

Updated by: Charles I. Schwartz, MD, FAAP, Clinical Assistant Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, General Pediatrician at PennCare for Kids, Phoenixville, PA. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.