Smallpox is a contagious disease caused by a virus. Smallpox virus has been eradicated worldwide through successful vaccination and treatment programs, and now exists only as a stored virus in a few research centers. Symptoms include a severe rash that leaves scars, fever, headache, vomiting and diarrhea.
Review Date 4/16/2019
Updated by: Michael Lehrer, MD, Clinical Associate Professor, Department of Dermatology, University of Pennsylvania Medical Center, Philadelphia, PA. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.