Tertiary Lyme disease is a late, persistent inflammatory disease characterized by skin changes, neurological and musculoskeletal symptoms caused by the bacterium Borrelia burgdorferi transmitted by the bite of a tick. Tertiary Lyme disease is indicated by chronic arthritis.
Review Date 7/21/2022
Updated by: Frank D. Brodkey, MD, FCCM, Associate Professor, Section of Pulmonary and Critical Care Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI. Also reviewed by David C. Dugdale, MD Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.