Tertiary Lyme disease is a late, persistent inflammatory disease characterized by skin changes, neurological and musculoskeletal symptoms caused by the bacterium Borrelia burgdorferi transmitted by the bite of a tick. Tertiary Lyme disease is indicated by chronic arthritis.
Review Date 5/1/2015
Updated by: Jatin M. Vyas, MD, PhD, Assistant Professor in Medicine, Harvard Medical School; Assistant in Medicine, Division of Infectious Disease, Department of Medicine, Massachusetts General Hospital, Boston, MA. Internal review and update on 09/01/2016 by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team. Editorial update 09/07/2017.