Tertiary Lyme disease is a late, persistent inflammatory disease characterized by skin changes, neurological and musculoskeletal symptoms caused by the bacterium Borrelia burgdorferi transmitted by the bite of a tick. Tertiary Lyme disease is indicated by chronic arthritis.
Review Date 7/13/2020
Updated by: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine, Seattle, WA. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.