The term "malignancy" refers to the presence of cancerous cells that have the ability to spread to other sites in the body (metastasize) or to invade nearby (locally) and destroy tissues. Malignant cells tend to have fast, uncontrolled growth and do not die normally due to changes in their genetic makeup.
Malignant cells that are resistant to treatment may return after all detectable traces of them have been removed or destroyed.
National Cancer Institute website. NCI dictionary of cancer terms. www.cancer.gov/publications/dictionaries/cancer-terms/def/malignancy. Accessed August 15, 2022.
Park BH. Cancer biology and genetics. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier; 2020:chap 171.
Review Date 8/15/2022
Updated by: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.