Leptospirosis is an infection. It occurs when you come in contact with leptospira bacteria.
These bacteria can be found in fresh water that has been soiled by animal urine. You may get infected if you come in contact with an infected animal. The infection occurs in warmer climates. Leptospirosis is not spread from person to person, except in very rare cases.
Risk factors include:
- Occupational exposure -- farmers, ranchers, slaughterhouse workers, trappers, veterinarians, loggers, sewer workers, rice field workers, and military personnel
- Recreational activities -- fresh water swimming, canoeing, kayaking, and trail biking in warm areas
- Household exposure -- pet dogs, domesticated livestock, rainwater catchment systems, and infected rodents
Weil disease, a severe form of leptospirosis, is rare in the continental United States. Hawaii has the highest number of cases in the United States.
Symptoms can take 2 to 26 days (average 10 days) to develop, and may include:
- Dry cough
- Muscle pain
- Nausea, vomiting, and diarrhea
- Shaking chills
Less common symptoms include:
Medicines to treat leptospirosis include:
Complicated or serious cases may need supportive care. You may need treatment in a hospital intensive care unit (ICU).
The outlook is generally good. However, a complicated case can be fatal if it is not treated promptly.
Complications may include:
- Jarisch-Herxheimer reaction when penicillin is given
- Severe bleeding
When to Contact a Medical Professional
Contact your health care provider if you have any symptoms of, or risk factors for, leptospirosis.
Avoid areas of stagnant water or floodwater, especially in tropical climates. If you are exposed to a high risk area take precaution to avoid infection. Wear protective clothing, shoes, or boots when near water or soil contaminated with animal urine. You can take doxycycline to decrease the risk.
Weil disease; Icterohemorrhagic fever; Swineherd's disease; Rice-field fever; Cane-cutter fever; Swamp fever; Mud fever; Hemorrhagic jaundice; Stuttgart disease; Canicola fever
Galloway RL, Stoddard RA, Schafer IJ. Leptospirosis. CDC Yellow Book 2018: Health Information for the International Traveler. Centers for Disease Control and Prevention. wwwnc.cdc.gov/travel/yellowbook/2018/infectious-diseases-related-to-travel/leptospirosis. Updated May 31, 2017. Accessed July 24, 2018.
Haake DA, Levett PN. Leptospira species (leptospirosis). In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases, Updated Edition. 8th ed. Philadelphia, PA: Elsevier Saunders; 2015:chap 241.
Muehlenbachs A, Zaki SR. Leptospirosis. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 25th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 323.
Review Date 7/12/2018
Updated by: Laura J. Martin, MD, MPH, ABIM Board Certified in Internal Medicine and Hospice and Palliative Medicine, Atlanta, GA. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.