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Fibrinolysis - primary or secondary

Fibrinolysis is a normal body process. It prevents blood clots that occur naturally from growing and causing problems.

Primary fibrinolysis refers to the normal breakdown of clots.

Secondary fibrinolysis is the breakdown of blood clots due to a medical disorder, medicine, or other cause. This may cause severe bleeding.

Causes

Blood clots form on a protein called fibrin. The breakdown of fibrin (fibrinolysis) can be due to:

  • Bacterial infections
  • Cancer
  • Intense exercise
  • Low blood sugar
  • Not enough oxygen to tissues

Your health care provider may give you medicines to help blood clots break down more quickly. This may be done if a blood clot causes a heart attack.

Alternative Names

Primary fibrinolysis; Secondary fibrinolysis

References

Schafer AI. Hemorrhagic disorders. In: Goldman L, Schafer AI, eds. Goldman's Cecil Medicine. 25th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 175.

Weitz JI. Hemostasis, Thrombosis, fibrinolysis, and cardiovascular disease. In: Mann DL, Zipes DP, Libby P, Bonow RO, Braunwald E, eds. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine. 10th ed. Philadelphia, PA: Elsevier Saunders; 2015:chap 82.

Weitz JI. Overview of hemostasis and thrombosis. In: Hoffman R, Benz EJ Jr., Silberstein LE, Heslop HE, Weitz JI, Anastasi J, eds. Hematology: Basic Principles and Practice. 6th ed. Philadelphia, PA: Elsevier Churchill Livingstone; 2013:chap 124.

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Review Date 2/1/2016

Updated by: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.

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