URL of this page: https://medlineplus.gov/druginfo/natural/1081.html

Mangosteen

What is it?

Mangosteen is a fruit used to make medicine.

Mangosteen is commonly taken by mouth for diarrhea and infections. It is also applied directly to the skin for eczema and other skin conditions. But there is limited scientific research to support these or other uses.

How effective is it?

Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.

The effectiveness ratings for MANGOSTEEN are as follows:

Insufficient evidence to rate effectiveness for...

  • Tired muscles because of exercise (muscle fatigue). Drinking mangosteen juice 1 hour before exercise doesn't seem improve how tired muscle get during exercise.
  • Diarrhea.
  • Dysentery.
  • Eczema.
  • Gonorrhea.
  • Menstrual disorders.
  • Thrush.
  • Tuberculosis.
  • Urinary tract infections (UTIs).
  • Other conditions.
More evidence is needed to rate the effectiveness of mangosteen for these uses.

How does it work?

Mangosteen contains chemicals that might act as antioxidants and fight infections, but more information is needed.

Are there safety concerns?

There is not enough reliable information to know if mangosteen products are safe for use as medicines.

Special precautions & warnings:

Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking mangosteen if you are pregnant or breast-feeding. Stay on the safe side and avoid use.

Bleeding disorders: Mangosteen might slow blood clotting. Taking mangosteen might increase the risk of bleeding in people with bleeding disorders.

Surgery: Mangosteen might slow blood clotting. Taking mangosteen might increase the risk of bleeding during or after surgery. Stop taking mangosteen 2 weeks before surgery.

Are there interactions with medications?

Moderate
Be cautious with this combination.
Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs)
Mangosteen might slow blood clotting and increase bleeding time. Taking mangosteen along with medications that also slow clotting might increase the chances of bruising and bleeding.

Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), dalteparin (Fragmin), dipyridamole (Persantine), enoxaparin (Lovenox), heparin, ticlopidine (Ticlid), warfarin (Coumadin), and others.

Are there interactions with herbs and supplements?

Herbs and supplements that might slow blood clotting
Mangosteen might increase the amount of time it takes for blood to clot. Taking it along with other herbs and supplements that slow blood clotting might slow blood clotting even more and might increase the risk of bleeding and bruising in some people. Some of these herbs include angelica, clove, danshen, garlic, ginger, ginkgo, Panax ginseng, red clover, turmeric, willow, and others.

Are there interactions with foods?

There are no known interactions with foods.

What dose is used?

The appropriate dose of mangosteen depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for mangosteen. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

Other names

Amibiasine, Fruit des Rois, Garcinia mangostana, Jus de Xango, Mang Cut, Manggis, Manggistan, Mangosta, Mangostan, Mangostán, Mangostana, Mangostanier, Mangostao, Mangostier, Mangoustan, Mangoustanier, Mangouste, Mangoustier, Manguita, Meseter, Queen of Fruit, Queen of Fruits, Sementah, Semetah, Xango, Xango Juice.

Methodology

To learn more about how this article was written, please see the Natural Medicines Comprehensive Database methodology.

References

  1. Chang CW, Huang TZ, Chang WH, Tseng YC, Wu YT, Hsu MC. Acute Garcinia mangostana (mangosteen) supplementation does not alleviate physical fatigue during exercise: a randomized, double-blind, placebo-controlled, crossover trial. J Int Soc Sports Nutr 2016;13:20. View abstract.
  2. Gutierrez-Orozco F and Failla ML. Biological activities and bioavailability of mangosteen xanthones: a critical review of the current evidence. Nutrients 2013;5:3163-83. View abstract.
  3. Chairungsrilerd, N., Furukawa, K., Tadano, T., Kisara, K., and Ohizumi, Y. Effect of gamma-mangostin through the inhibition of 5-hydroxy-tryptamine2A receptors in 5-fluoro-alpha-methyltryptamine-induced head-twitch responses of mice. Br J Pharmacol. 1998;123:855-862. View abstract.
  4. Furukawa, K., Chairungsrilerd, N., Ohta, T., Nozoe, S., and Ohizumi, Y. [Novel types of receptor antagonists from the medicinal plant Garcinia mangostana]. Nippon Yakurigaku Zasshi 1997;110 Suppl 1:153P-158P. View abstract.
  5. Chanarat, P., Chanarat, N., Fujihara, M., and Nagumo, T. Immunopharmacological activity of polysaccharide from the pericarb of mangosteen garcinia: phagocytic intracellular killing activities. J Med Assoc.Thai. 1997;80 Suppl 1:S149-S154. View abstract.
  6. Iinuma, M., Tosa, H., Tanaka, T., Asai, F., Kobayashi, Y., Shimano, R., and Miyauchi, K. Antibacterial activity of xanthones from guttiferaeous plants against methicillin-resistant Staphylococcus aureus. J Pharm Pharmacol. 1996;48:861-865. View abstract.
  7. Chen, S. X., Wan, M., and Loh, B. N. Active constituents against HIV-1 protease from Garcinia mangostana. Planta Med 1996;62:381-382. View abstract.
  8. Gopalakrishnan, C., Shankaranarayanan, D., Kameswaran, L., and Nazimudeen, S. K. Effect of mangostin, a xanthone from Garcinia mangostana Linn. in immunopathological & inflammatory reactions. Indian J Exp.Biol 1980;18:843-846. View abstract.
  9. Shankaranarayan, D., Gopalakrishnan, C., and Kameswaran, L. Pharmacological profile of mangostin and its derivatives. Arch Int Pharmacodyn.Ther 1979;239:257-269. View abstract.
  10. Zheng, M. S. and Lu, Z. Y. Antiviral effect of mangiferin and isomangiferin on herpes simplex virus. Chin Med J (Engl.) 1990;103:160-165. View abstract.
  11. Jung, H. A., Su, B. N., Keller, W. J., Mehta, R. G., and Kinghorn, A. D. Antioxidant xanthones from the pericarp of Garcinia mangostana (Mangosteen). J Agric.Food Chem 3-22-2006;54:2077-2082. View abstract.
  12. Suksamrarn, S., Komutiban, O., Ratananukul, P., Chimnoi, N., Lartpornmatulee, N., and Suksamrarn, A. Cytotoxic prenylated xanthones from the young fruit of Garcinia mangostana. Chem Pharm Bull (Tokyo) 2006;54:301-305. View abstract.
  13. Chomnawang, M. T., Surassmo, S., Nukoolkarn, V. S., and Gritsanapan, W. Antimicrobial effects of Thai medicinal plants against acne-inducing bacteria. J Ethnopharmacol. 10-3-2005;101(1-3):330-333. View abstract.
  14. Sakagami, Y., Iinuma, M., Piyasena, K. G., and Dharmaratne, H. R. Antibacterial activity of alpha-mangostin against vancomycin resistant Enterococci (VRE) and synergism with antibiotics. Phytomedicine. 2005;12:203-208. View abstract.
  15. Matsumoto, K., Akao, Y., Yi, H., Ohguchi, K., Ito, T., Tanaka, T., Kobayashi, E., Iinuma, M., and Nozawa, Y. Preferential target is mitochondria in alpha-mangostin-induced apoptosis in human leukemia HL60 cells. Bioorg.Med Chem 11-15-2004;12:5799-5806. View abstract.
  16. Nakatani, K., Yamakuni, T., Kondo, N., Arakawa, T., Oosawa, K., Shimura, S., Inoue, H., and Ohizumi, Y. gamma-Mangostin inhibits inhibitor-kappaB kinase activity and decreases lipopolysaccharide-induced cyclooxygenase-2 gene expression in C6 rat glioma cells. Mol.Pharmacol. 2004;66:667-674. View abstract.
  17. Moongkarndi, P., Kosem, N., Luanratana, O., Jongsomboonkusol, S., and Pongpan, N. Antiproliferative activity of Thai medicinal plant extracts on human breast adenocarcinoma cell line. Fitoterapia 2004;75(3-4):375-377. View abstract.
  18. Sato, A., Fujiwara, H., Oku, H., Ishiguro, K., and Ohizumi, Y. Alpha-mangostin induces Ca2+-ATPase-dependent apoptosis via mitochondrial pathway in PC12 cells. J Pharmacol.Sci 2004;95:33-40. View abstract.
  19. Moongkarndi, P., Kosem, N., Kaslungka, S., Luanratana, O., Pongpan, N., and Neungton, N. Antiproliferation, antioxidation and induction of apoptosis by Garcinia mangostana (mangosteen) on SKBR3 human breast cancer cell line. J Ethnopharmacol. 2004;90:161-166. View abstract.
  20. Jinsart, W., Ternai, B., Buddhasukh, D., and Polya, G. M. Inhibition of wheat embryo calcium-dependent protein kinase and other kinases by mangostin and gamma-mangostin. Phytochemistry 1992;31:3711-3713. View abstract.
  21. Nakatani, K., Atsumi, M., Arakawa, T., Oosawa, K., Shimura, S., Nakahata, N., and Ohizumi, Y. Inhibitions of histamine release and prostaglandin E2 synthesis by mangosteen, a Thai medicinal plant. Biol Pharm Bull. 2002;25:1137-1141. View abstract.
  22. Nakatani, K., Nakahata, N., Arakawa, T., Yasuda, H., and Ohizumi, Y. Inhibition of cyclooxygenase and prostaglandin E2 synthesis by gamma-mangostin, a xanthone derivative in mangosteen, in C6 rat glioma cells. Biochem.Pharmacol. 1-1-2002;63:73-79. View abstract.
  23. Wong LP, Klemmer PJ. Severe lactic acidosis associated with juice of the mangosteen fruit Garcinia mangostana. Am J Kidney Dis 2008;51:829-33. View abstract.
  24. Voravuthikunchai SP, Kitpipit L. Activity of medicinal plant extracts against hospital isolates of methicillin-resistant Staphylococcus aureus. Clin Microbiol Infect 2005;11:510-2. View abstract.
  25. Chairungsrilerd N, Furukawa K, Ohta T, et al. Histaminergic and serotonergic receptor blocking substances from the medicinal plant Garcinia mangostana. Planta Med 1996;62:471-2. View abstract.
  26. Nilar, Harrison LJ. Xanthones from the heartwood of Garcinia mangostana. Phytochemistry 2002;60:541-8. View abstract.
  27. Ho CK, Huang YL, Chen CC. Garcinone E, a xanthone derivative, has potent cytotoxic effect against hepatocellular carcinoma cell lines. Planta Med 2002;68:975-9. View abstract.
  28. Suksamrarn S, Suwannapoch N, Phakhodee W, et al. Antimycobacterial activity of prenylated xanthones from the fruits of Garcinia mangostana. Chem Pharm Bull (Tokyo) 2003;51:857-9. View abstract.
  29. Matsumoto K, Akao Y, Kobayashi E, et al. Induction of aptosis by xanthones from mangosteen in human leukemia cell lines. J Nat Prod 2003;66:1124-7. View abstract.
Last reviewed - 11/12/2018