What is it?
Mangosteen is used for obesity and a serious gum infection (periodontitis). It is also used for muscle strength, diarrhea, and skin conditions, but there is no good scientific evidence to support these uses.
How effective is it?
Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
The effectiveness ratings for MANGOSTEEN are as follows:
Possibly effective for...
- Obesity. Taking a product containing mangosteen and Sphaeranthus indicus (Meratrim) twice daily seems to help people who are obese or overweight to lose weight.
- A serious gum infection (periodontitis). Applying a gel containing 4% mangosteen powder to the gums after a special cleaning helps reduce loose teeth and bleeding in people with a serious gum disease.
Insufficient evidence to rate effectiveness for...
- Muscle fatigue. Drinking mangosteen juice 1 hour before exercise doesn't seem to improve how tired the muscles get during exercise.
- Muscle strength.
- Menstrual disorders.
- Urinary tract infections (UTIs).
- Other conditions.
How does it work?
Are there safety concerns?
When applied to the gums: Mangosteen is POSSIBLY SAFE when applied to the gums as a 4% gel.
Special precautions & warnings:Pregnancy and breast-feeding: There isn't enough reliable information to know if mangosteen is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.
Bleeding disorders: Mangosteen might slow blood clotting. Taking mangosteen might increase the risk of bleeding in people with bleeding disorders.
Surgery: Mangosteen might slow blood clotting. Taking mangosteen might increase the risk of bleeding during or after surgery. Stop taking mangosteen 2 weeks before surgery.
Are there interactions with medications?
- Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs)
- Mangosteen might slow blood clotting and increase bleeding time. Taking mangosteen along with medications that also slow clotting might increase the chances of bruising and bleeding.
Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), dalteparin (Fragmin), dipyridamole (Persantine), enoxaparin (Lovenox), heparin, ticlopidine (Ticlid), warfarin (Coumadin), and others.
Are there interactions with herbs and supplements?
- Herbs and supplements that might slow blood clotting
- Mangosteen might increase the amount of time it takes for blood to clot. Taking it along with other herbs and supplements that slow blood clotting might slow blood clotting even more and might increase the risk of bleeding and bruising in some people. Some of these herbs include angelica, clove, danshen, garlic, ginger, ginkgo, Panax ginseng, red clover, turmeric, willow, and others.
Are there interactions with foods?
- There are no known interactions with foods.
What dose is used?
- Obesity: 400 mg of a product containing a mixture of mangosteen and Sphaeranthus indicus (Meratrim, Laila Nutraceuticals) has been taken twice daily for 8-16 weeks.
- A serious gum infection (periodontitis): A gel containing 4% mangosteen has been applied to the gums following a special cleaning of the teeth and gums.
To learn more about how this article was written, please see the Natural Medicines Comprehensive Database methodology.
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