URL of this page: https://medlineplus.gov/druginfo/natural/1081.html

Mangosteen

What is it?

Mangosteen is a plant used to make medicine. The fruit rind is most commonly used, but other parts of the plant, like the seeds, leaves, and bark, are also used.

Mangosteen is used for obesity and a serious gum infection (periodontitis). It is also used for muscle strength, diarrhea, and skin conditions, but there is no good scientific evidence to support these uses.

How effective is it?

Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.

The effectiveness ratings for MANGOSTEEN are as follows:

Possibly effective for...

  • Obesity. Taking a product containing mangosteen and Sphaeranthus indicus (Meratrim) twice daily seems to help people who are obese or overweight to lose weight.
  • A serious gum infection (periodontitis). Applying a gel containing 4% mangosteen powder to the gums after a special cleaning helps reduce loose teeth and bleeding in people with a serious gum disease.

Insufficient evidence to rate effectiveness for...

  • Muscle fatigue. Drinking mangosteen juice 1 hour before exercise doesn't seem to improve how tired the muscles get during exercise.
  • Muscle strength.
  • Diarrhea.
  • Dysentery.
  • Eczema.
  • Gonorrhea.
  • Menstrual disorders.
  • Thrush.
  • Tuberculosis.
  • Urinary tract infections (UTIs).
  • Other conditions.
More evidence is needed to rate the effectiveness of mangosteen for these uses.

How does it work?

Mangosteen contains chemicals that might act as antioxidants and fight infections, but more information is needed.

Are there safety concerns?

When taken by mouth: Mangosteen is POSSIBLY SAFE when taken for up to 12-16 weeks. It might cause constipation, bloating, nausea, vomiting, and tiredness.

When applied to the gums: Mangosteen is POSSIBLY SAFE when applied to the gums as a 4% gel.

Special precautions & warnings:

Pregnancy and breast-feeding: There isn't enough reliable information to know if mangosteen is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Bleeding disorders: Mangosteen might slow blood clotting. Taking mangosteen might increase the risk of bleeding in people with bleeding disorders.

Surgery: Mangosteen might slow blood clotting. Taking mangosteen might increase the risk of bleeding during or after surgery. Stop taking mangosteen 2 weeks before surgery.

Are there interactions with medications?

Moderate
Be cautious with this combination.
Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs)
Mangosteen might slow blood clotting and increase bleeding time. Taking mangosteen along with medications that also slow clotting might increase the chances of bruising and bleeding.

Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), dalteparin (Fragmin), dipyridamole (Persantine), enoxaparin (Lovenox), heparin, ticlopidine (Ticlid), warfarin (Coumadin), and others.

Are there interactions with herbs and supplements?

Herbs and supplements that might slow blood clotting
Mangosteen might increase the amount of time it takes for blood to clot. Taking it along with other herbs and supplements that slow blood clotting might slow blood clotting even more and might increase the risk of bleeding and bruising in some people. Some of these herbs include angelica, clove, danshen, garlic, ginger, ginkgo, Panax ginseng, red clover, turmeric, willow, and others.

Are there interactions with foods?

There are no known interactions with foods.

What dose is used?

The following doses have been studied in scientific research:

ADULTS

BY MOUTH:
  • Obesity: 400 mg of a product containing a mixture of mangosteen and Sphaeranthus indicus (Meratrim, Laila Nutraceuticals) has been taken twice daily for 8-16 weeks.
ON THE GUMS:
  • A serious gum infection (periodontitis): A gel containing 4% mangosteen has been applied to the gums following a special cleaning of the teeth and gums.

Other names

Amibiasine, Fruit des Rois, Garcinia mangostana, Jus de Xango, Mang Cut, Manggis, Manggistan, Mangosta, Mangostan, Mangostán, Mangostana, Mangostanier, Mangostao, Mangostier, Mangoustan, Mangoustanier, Mangouste, Mangoustier, Manguita, Meseter, Queen of Fruit, Queen of Fruits, Sementah, Semetah, Xango, Xango Juice.

Methodology

To learn more about how this article was written, please see the Natural Medicines Comprehensive Database methodology.

References

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  2. Stern JS, Peerson J, Mishra AT, Sadasiva Rao MV, Rajeswari KP. Efficacy and tolerability of a novel herbal formulation for weight management. Obesity (SilverSpring) 2013;21:921-7. View abstract.
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  4. Suthammarak W, Numpraphrut P, Charoensakdi R, et al. Antioxidant-enhancing property of the polar fraction of mangosteen pericarp extract and evaluation of its safety in humans. Oxid Med Cell Longev 2016;2016:1293036. View abstract.
  5. Kudiganti V, Kodur RR, Kodur SR, Halemane M, Deep DK. Efficacy and tolerability of Meratrim for weight management: a randomized, double-blind, placebo-controlled study in healthy overweight human subjects. Lipids Health Dis 2016;15:136. View abstract.
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  22. Nakatani, K., Yamakuni, T., Kondo, N., Arakawa, T., Oosawa, K., Shimura, S., Inoue, H., and Ohizumi, Y. gamma-Mangostin inhibits inhibitor-kappaB kinase activity and decreases lipopolysaccharide-induced cyclooxygenase-2 gene expression in C6 rat glioma cells. Mol.Pharmacol. 2004;66:667-674. View abstract.
  23. Moongkarndi, P., Kosem, N., Luanratana, O., Jongsomboonkusol, S., and Pongpan, N. Antiproliferative activity of Thai medicinal plant extracts on human breast adenocarcinoma cell line. Fitoterapia 2004;75(3-4):375-377. View abstract.
  24. Sato, A., Fujiwara, H., Oku, H., Ishiguro, K., and Ohizumi, Y. Alpha-mangostin induces Ca2+-ATPase-dependent apoptosis via mitochondrial pathway in PC12 cells. J Pharmacol.Sci 2004;95:33-40. View abstract.
  25. Moongkarndi, P., Kosem, N., Kaslungka, S., Luanratana, O., Pongpan, N., and Neungton, N. Antiproliferation, antioxidation and induction of apoptosis by Garcinia mangostana (mangosteen) on SKBR3 human breast cancer cell line. J Ethnopharmacol. 2004;90:161-166. View abstract.
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  28. Nakatani, K., Nakahata, N., Arakawa, T., Yasuda, H., and Ohizumi, Y. Inhibition of cyclooxygenase and prostaglandin E2 synthesis by gamma-mangostin, a xanthone derivative in mangosteen, in C6 rat glioma cells. Biochem.Pharmacol. 1-1-2002;63:73-79. View abstract.
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Last reviewed - 10/08/2020