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Lamivudine

pronounced as (la mi' vyoo deen)

IMPORTANT WARNING:

Medications that are similar to lamivudine have caused serious damage to the liver and a life-threatening condition called lactic acidosis (buildup of lactic acid in the blood) when they were used alone or in combination with other medications that treat human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS). The risk that you will develop lactic acidosis may be higher if you are a woman, if you are overweight, or if you have been treated with medications for HIV for a long time. Tell your doctor if you have or have ever had liver disease. If you experience any of the following symptoms, call your doctor immediately: nausea; vomiting; loss of appetite; excessive tiredness; weakness; dizziness; lightheadedness; fast or irregular heartbeat; trouble breathing; dark yellow or brown urine; unusual bleeding or bruising; flu-like symptoms; light-colored bowel movements; yellowing of the skin or eyes; pain in the upper right part of your stomach; feeling cold, especially in the arms or legs; or muscle pain that is different than any muscle pain you usually experience.

Tell your doctor if you have or think you may have hepatitis B virus infection (HBV; an ongoing liver infection). Your doctor may test you to see if you have HBV before you begin your treatment with lamivudine. If you have HBV and you take lamivudine, your condition may suddenly worsen when you stop taking lamivudine. Your doctor will examine you and order lab tests regularly for several months after you stop taking lamivudine to see if your HBV has worsened.

Epivir tablets and liquid (used to treat human immunodeficiency virus [HIV]) are not interchangeable with Epivir-HBV tablets and liquid (used to treat hepatitis B infection). Epivir contains a higher dose of lamivudine than Epivir-HBV. Treatment with Epivir-HBV in patients infected with HIV may cause the HIV virus to be less treatable with lamivudine and other medicines. If you have both HIV and hepatitis B, you should take only Epivir. If you are taking Epivir-HBV for hepatitis B infection, talk to your doctor about your risks for HIV infection.

Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests to check your body's response to lamivudine.

Talk to your doctor about the risks of taking lamivudine.

Why is this medication prescribed?

Lamivudine (Epivir) is used along with other medications to treat human immunodeficiency virus (HIV) infection. Lamivudine (Epivir-HBV) is used to treat hepatitis B infection. Lamivudine is in a class of medications called nucleoside reverse transcriptase inhibitors (NRTIs). It works by decreasing the amount of HIV and hepatitis B in the blood. Although lamivudine does not cure HIV, it may decrease your chance of developing acquired immunodeficiency syndrome (AIDS) and HIV-related illnesses such as serious infections or cancer. Taking these medications along with practicing safer sex and making other life-style changes may decrease the risk of transmitting (spreading) the HIV or hepatitis B virus to other people.

How should this medicine be used?

Lamivudine comes as a tablet and liquid to take by mouth. Lamivudine (Epivir) is usually taken once or twice a day with or without food. Lamivudine (Epivir-HBV) is usually taken once a day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take lamivudine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Lamivudine controls HIV and hepatitis B infection and but does not cure them. Continue to take lamivudine even if you feel well. Do not stop taking lamivudine without talking to your doctor. When your supply of lamivudine starts to run low, get more from your doctor or pharmacist. If you miss doses or stop taking lamivudine, your condition may become more difficult to treat.

Other uses for this medicine

Lamivudine is also used sometimes in combination with other medications to treat healthcare workers or other individuals exposed to HIV infection after accidental contact with HIV-contaminated blood, tissues, or other body fluids. Talk to your doctor about the possible risks of using this drug for your condition.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before taking lamivudine,

  • tell your doctor and pharmacist if you are allergic to lamivudine, any other medications, or any of the ingredients in lamivudine tablets or solution. Ask your pharmacist for a list of the ingredients.
  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention the following: interferon alfa (Intron A), ribavirin (Copegus, Rebetol), and trimethoprim/sulfamethoxazole (Bactrim, Septra) .
  • tell your doctor if you have or have ever had hepatitis B, hepatitis C, kidney disease, or pancreas disease (in children only).
  • tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking lamivudine, call your doctor. You should not breastfeed if you are infected with HIV or if you are taking lamivudine.
  • you should know that your body fat may increase or move to different areas of your body such as your breasts and upper back.
  • you should know that while you are taking medications to treat HIV infection, your immune system may get stronger and begin to fight other infections that were already in your body. This may cause you to develop symptoms of those infections. If you have new or worsening symptoms after starting treatment with lamivudine, be sure to tell your doctor.
  • if you have diabetes, you should know that there are 3 grams of sucrose in each tablespoon (15 mL) of lamivudine solution.

What should I do if I forget a dose?

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can this medication cause?

Lamivudine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • diarrhea
  • headache
  • fatigue
  • fever
  • chills
  • loss of appetite
  • trouble sleeping
  • depression
  • stuffy nose
  • cough
  • muscle pain

If you experience any of the following symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately:

  • rash
  • vomiting (in children)
  • nausea (in children)
  • ongoing pain that begins in the stomach area but may spread to the back (in children)
  • numbness, tingling, or burning in the fingers or toes

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). The liquid does not need to be refrigerated; however, it should be stored in a cool place. Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

In case of emergency/overdose

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

What other information should I know?

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Brand names

  • Epivir®
  • Epivir-HBV®

Brand names of combination products

  • Epzicom® (containing Abacavir, Lamivudine)
  • Triumeq® (containing Abacavir, Dolutegravir, Lamivudine)
  • Trizivir® (containing Abacavir, Lamivudine, Zidovudine)

Other names

  • 3TC
Last Revised - 12/15/2016