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URL of this page: https://medlineplus.gov/druginfo/meds/a682619.html

Pseudoephedrine

pronounced as (soo doe e fed' rin)

Why is this medication prescribed?

Pseudoephedrine is used to relieve nasal congestion caused by colds, allergies, and hay fever. It is also used to temporarily relieve sinus congestion and pressure. Pseudoephedrine will relieve symptoms but will not treat the cause of the symptoms or speed recovery. Pseudoephedrine is in a class of medications called nasal decongestants. It works by causing narrowing of the blood vessels in the nasal passages.

How should this medicine be used?

Pseudoephedrine comes as a regular tablet, a 12-hour extended-release (long-acting) tablet, a 24-hour extended-release tablet, and a solution (liquid) to be taken by mouth. The regular tablets and liquid are usually taken every 4 to 6 hours. The 12-hour extended-release tablets usually are taken every 12 hours, and you should not take more than two doses in a 24-hour period. The 24-hour extended-release tablets usually are taken once a day, and you should not take more than one dose in a 24-hour period. To help prevent trouble sleeping, take the last dose of the day several hours before bedtime. Follow the directions on the package label or on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take pseudoephedrine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor or directed on the label.

Pseudoephedrine comes alone and in combination with other medications. Ask your doctor or pharmacist for advice on which product is best for your symptoms. Check nonprescription cough and cold product labels carefully before using 2 or more products at the same time. These products may contain the same active ingredient(s) and taking them together could cause you to receive an overdose. This is especially important if you will be giving cough and cold medications to a child.

Nonprescription cough and cold combination products, including products that contain pseudoephedrine, can cause serious side effects or death in young children. Do not give nonprescription pseudoephedrine products to children younger than 4 years of age. If you give these products to children 4-11 years of age, use caution and follow the package directions carefully. Do not give pseudoephedrine extended-release tablets to children younger than 12 years of age.

If you are giving pseudoephedrine or a combination product that contains pseudoephedrine to a child, read the package label carefully to be sure that it is the right product for a child of that age. Do not give pseudoephedrine products that are made for adults to children.

Before you give a pseudoephedrine product to a child, check the package label to find out how much medication the child should receive. Give the dose that matches the child's age on the chart. Ask the child's doctor if you don't know how much medication to give the child.

If you are taking the liquid, do not use a household spoon to measure your dose. Use the measuring spoon or cup that came with the medication or use a spoon made especially for measuring medication.

If your symptoms do not get better within 7 days or if you have a fever, stop taking pseudoephedrine and call your doctor.

Swallow the extended-release tablets whole; do not break, crush, or chew them.

Other uses for this medicine

This medication is also sometimes used to prevent ear pain and blockage caused by pressure changes during air travel or underwater diving. Talk to your doctor or pharmacist for more information.

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before taking pseudoephedrine,

  • tell your doctor and pharmacist if you are allergic to pseudoephedrine, any other medications, or any of the inactive ingredients in the pseudoephedrine product you plan to take. Check the package label for a list of the ingredients.
  • tell your doctor or pharmacist if you are taking the following medications or have stopped taking them within the past two weeks: monoamine oxidase (MAO) inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate).
  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take while taking pseudoephedrine. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.n
  • tell your doctor if you have or have ever had high blood pressure, glaucoma (a condition in which increased pressure in the eye can lead to gradual loss of vision), diabetes, difficulty urinating (due to an enlarged prostate gland), or thyroid or heart disease. If you plan to take the 24-hour extended-release tablets, tell your doctor if you have had a narrowing or blockage of your digestive system.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking pseudoephedrine, call your doctor.
  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking pseudoephedrine.

What special dietary instructions should I follow?

Foods and drinks that contain large amounts of caffeine can make the side effects of pseudoephedrine worse.

What should I do if I forget a dose?

This medication is usually taken as needed. If your doctor has told you to take pseudoephedrine regularly, take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can this medication cause?

Pseudoephedrine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • restlessness
  • nausea
  • vomiting
  • weakness
  • headache

Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately:

  • nervousness
  • dizziness
  • difficulty sleeping
  • stomach pain
  • difficulty breathing
  • fast, pounding, or irregular heartbeat

Pseudoephedrine may cause other side effects. Call your doctor if you have any unusual problems while you are taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (https://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (https://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. https://www.upandaway.org

In case of emergency/overdose

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

What other information should I know?

If you are taking the 24-hour extended-release tablets, you may notice something that looks like a tablet in your stool. This is just the empty tablet shell, and this does not mean that you did not get your complete dose of medication.

Ask your pharmacist any questions you have about pseudoephedrine.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Brand names

  • Afrinol®
  • Cenafed®
  • Children's Sudafed Nasal Decongestant®
  • Congestaclear®
  • Efidac®
  • Myfedrine®
  • Pseudocot®
  • Ridafed®
  • Silfedrine®
  • Sudafed 12/24 Hour®
  • Sudafed Congestion®
  • Sudodrin®
  • SudoGest®
  • Sudrine®
  • Superfed®
  • Suphedrin®
  • Allegra-D® (as a combination product containing Fexofenadine, Pseudoephedrine)

Brand names of combination products

  • AccuHist DM® (containing Brompheniramine, Dextromethorphan, Guaifenesin, Pseudoephedrine)§
  • Advil Allergy Sinus® (containing Chlorpheniramine, Ibuprofen, Pseudoephedrine)
  • Advil Cold and Sinus® (containing Ibuprofen, Pseudoephedrine)
  • Alavert Allergy and Sinus D-12® (containing Loratadine, Pseudoephedrine)
  • Aldex GS® (containing Guaifenesin, Pseudoephedrine)
  • Aldex GS DM® (containing Dextromethorphan, Guaifenesin, Pseudoephedrine)
  • Aleve-D Sinus and Cold® (containing Naproxen, Pseudoephedrine)
  • Allergy Relief D® (containing Cetirizine, Pseudoephedrine)
  • Ambifed® (containing Guaifenesin, Pseudoephedrine)§
  • Ambifed DM® (containing Dextromethorphan, Guaifenesin, Pseudoephedrine)§
  • Biodec DM® (containing Dextromethorphan, Pseudoephedrine)§
  • BP 8® (containing Dextromethorphan, Guaifenesin, Pseudoephedrine)§
  • Brofed® (containing Brompheniramine, Pseudoephedrine)§
  • Bromdex® (containing Brompheniramine, Dextromethorphan, Pseudoephedrine)§
  • Bromfed® (containing Brompheniramine, Pseudoephedrine)§
  • Bromfed DM® (containing Brompheniramine, Dextromethorphan, Pseudoephedrine)
  • Bromhist DM® (containing Brompheniramine, Dextromethorphan, Guaifenesin, Pseudoephedrine)§
  • Bromphenex DM® (containing Brompheniramine, Dextromethorphan, Pseudoephedrine)
  • Bromuphed® (containing Brompheniramine, Pseudoephedrine)§
  • Bromuphed PD® (containing Brompheniramine, Pseudoephedrine)§
  • Brotapp® (containing Brompheniramine, Pseudoephedrine)
  • Brotapp-DM Cold and Cough® (containing Brompheniramine, Dextromethorphan, Pseudoephedrine)
  • Brovex PSB® (containing Brompheniramine, Pseudoephedrine)
  • Brovex PSB DM® (containing Brompheniramine, Dextromethorphan, Pseudoephedrine)
  • Brovex SR® (containing Brompheniramine, Pseudoephedrine)§
  • Carbofed DM® (containing Brompheniramine, Dextromethorphan, Pseudoephedrine)§
  • Certuss-D® (containing Chlophedianol, Guaifenesin, Pseudoephedrine)
  • Cetiri-D® (containing Cetirizine, Pseudoephedrine)
  • Children's Advil Cold® (containing Ibuprofen, Pseudoephedrine)
  • Children's Motrin Cold® (containing Ibuprofen, Pseudoephedrine)
  • Chlorfed A SR® (containing Chlorpheniramine, Pseudoephedrine)§
  • Clarinex-D® (containing Desloratadine, Pseudoephedrine)
  • Claritin-D® (containing Loratadine, Pseudoephedrine)
  • Coldamine® (containing Chlorpheniramine, Methscopolamine, Pseudoephedrine)§
  • Coldmist DM® (containing Dextromethorphan, Guaifenesin, Pseudoephedrine)§
  • Coldmist LA® (containing Guaifenesin, Pseudoephedrine)§
  • Colfed A® (containing Chlorpheniramine, Pseudoephedrine)§
  • Corzall® (containing Carbetapentane, Pseudoephedrine)§
  • Dallergy PSE® (containing Chlorpheniramine, Methscopolamine, Pseudoephedrine)§
  • Deconamine® (containing Chlorpheniramine, Pseudoephedrine)§
  • Deconomed SR® (containing Chlorpheniramine, Pseudoephedrine)§
  • Defen LA® (containing Guaifenesin, Pseudoephedrine)§
  • Dimetane DX® (containing Brompheniramine, Dextromethorphan, Pseudoephedrine)
  • Drixoral® (containing Dexbrompheniramine, Pseudoephedrine)
  • Drymax® (containing Chlorpheniramine, Methscopolamine, Pseudoephedrine)§
  • Dynahist ER® (containing Chlorpheniramine, Pseudoephedrine)§
  • EndaCof-DC® (containing Codeine, Pseudoephedrine)
  • EndaCof-PD® (containing Brompheniramine, Dextromethorphan, Pseudoephedrine)§
  • Entex PSE® (containing Guaifenesin, Pseudoephedrine)§
  • Exall D® (containing Carbetapentane, Guaifenesin, Pseudoephedrine)§
  • ExeFen DMX® (containing Dextromethorphan, Guaifenesin, Pseudoephedrine)
  • ExeFen IR® (containing Guaifenesin, Pseudoephedrine)
  • Guaidex TR® (containing Chlorpheniramine, Dextromethorphan, Guaifenesin, Methscopolamine, Pseudoephedrine)§
  • Hexafed® (containing Dexchlorpheniramine, Pseudoephedrine)§
  • Histacol DM® (containing Brompheniramine, Guaifenesin, Dexchlorpheniramine, Pseudoephedrine)§
  • Histex® (containing Chlorpheniramine, Pseudoephedrine)§
  • Lodrane® (containing Brompheniramine, Pseudoephedrine)§
  • LoHist-D® (containing Chlorpheniramine, Pseudoephedrine)§
  • LoHist-PD® (containing Brompheniramine, Pseudoephedrine)§
  • LoHist-PSB® (containing Brompheniramine, Pseudoephedrine)
  • LoHist-PSB-DM® (containing Brompheniramine, Dextromethorphan, Pseudoephedrine)
  • Lortuss DM® (containing Dextromethorphan, Doxylamine, Pseudoephedrine)
  • Lortuss EX® (containing Codeine, Guaifenesin, Pseudoephedrine)
  • Lortuss LQ® (containing Doxylamine, Pseudoephedrine)
  • Medent DM® (containing Dextromethorphan, Guaifenesin, Pseudoephedrine)§
  • Medent LD® (containing Guaifenesin, Pseudoephedrine)§
  • Mintex® (containing Chlorpheniramine, Pseudoephedrine)§
  • Mucinex D® (containing Guaifenesin, Pseudoephedrine)
  • Myphetane Dx® (containing Brompheniramine, Dextromethorphan, Pseudoephedrine)§
  • Nalex® (containing Guaifenesin, Pseudoephedrine)§
  • Nasatab LA® (containing Guaifenesin, Pseudoephedrine)§
  • Neutrahist® (containing Chlorpheniramine, Pseudoephedrine)§
  • Notuss-NXD® (containing Chlorcyclizine, Codeine, Pseudoephedrine)§
  • Pediahist DM® (containing Brompheniramine, Dextromethorphan, Guaifenesin, Pseudoephedrine)§
  • Polyvent® (containing Guaifenesin, Pseudoephedrine)§
  • Pseudodine® (containing Pseudoephedrine, Triprolidine)
  • Relcof PSE® (containing Chlorpheniramine, Methscopolamine, Pseudoephedrine)§
  • Respa 1st® (containing Guaifenesin, Pseudoephedrine)§
  • Respaire® (containing Guaifenesin, Pseudoephedrine)§
  • Respivent D® (containing Chlorpheniramine, Methscopolamine, Pseudoephedrine)§
  • Rezira® (containing Hydrocodone, Pseudoephedrine)
  • Rondamine DM® (containing Dextromethorphan, Pseudoephedrine)§
  • Rondec® (containing Brompheniramine, Pseudoephedrine)§
  • Rondec DM® (containing Dextromethorphan, Pseudoephedrine)§
  • Ru-Tuss DM® (containing Dextromethorphan, Guaifenesin, Pseudoephedrine)§
  • Semprex-D® (containing Acrivastine, Pseudoephedrine)
  • Suclor® (containing Chlorpheniramine, Pseudoephedrine)§
  • Sudafed 12 Hour Pressure/Pain® (containing Naproxen, Pseudoephedrine)
  • Sudafed Triple Action® (containing Acetaminophen, Guaifenesin, Pseudoephedrine)
  • Sudahist® (containing Chlorpheniramine, Pseudoephedrine)§
  • Sudatex DM® (containing Dextromethorphan, Guaifenesin, Pseudoephedrine)§
  • Sudatrate® (containing Methscopolamine, Pseudoephedrine)§
  • Tekral® (containing Diphenhydramine, Pseudoephedrine)§
  • Tenar DM® (containing Dextromethorphan, Guaifenesin, Pseudoephedrine)§
  • Tenar PSE® (containing Guaifenesin, Pseudoephedrine)§
  • Theraflu Max-D Severe Cold and Flu® (containing Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine)
  • Touro CC® (containing Dextromethorphan, Guaifenesin, Pseudoephedrine)§
  • Touro LA® (containing Guaifenesin, Pseudoephedrine)§
  • Triacin® (containing Pseudoephedrine, Triprolidine)
  • Trikof D® (containing Dextromethorphan, Guaifenesin, Pseudoephedrine)§
  • Trispec PSE® (containing Dextromethorphan, Guaifenesin, Pseudoephedrine)§
  • Tussafed LA® (containing Dextromethorphan, Guaifenesin, Pseudoephedrine)§
  • Tylenol Sinus Severe Congestion Daytime® (containing Acetaminophen, Guaifenesin, Pseudoephedrine)
  • Vanacof® (containing Chlophedianol, Dexchlorpheniramine, Pseudoephedrine)
  • Vanacof DX® (containing Chlophedianol, Guaifenesin, Pseudoephedrine)
  • Viravan P® (containing Pseudoephedrine, Pyrilamine)§
  • Viravan PDM® (containing Dextromethorphan, Pseudoephedrine, Pyrilamine)§
  • Z-Cof DM® (containing Dextromethorphan, Guaifenesin, Pseudoephedrine)§
  • Zodryl DEC® (containing Codeine, Guaifenesin, Pseudoephedrine)
  • Zutripro® (containing Chlorpheniramine, Hydrocodone, Pseudoephedrine)
  • Zymine DRX® (containing Pseudoephedrine, Triprolidine)§
  • Zyrtec-D® (containing Cetirizine, Pseudoephedrine)

This branded product is no longer on the market. Generic alternatives may be available.

§ These products are not currently approved by the FDA for safety, effectiveness, and quality. Federal law generally requires that prescription drugs in the U.S. be shown to be both safe and effective prior to marketing. Please see the FDA website for more information on unapproved drugs (https://www.fda.gov/AboutFDA/Transparency/Basics/ucm213030.htm) and the approval process (https://www.fda.gov/Drugs/ResourcesForYou/Consumers/ucm054420.htm).

Last Revised - 02/15/2018