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URL of this page: https://medlineplus.gov/druginfo/meds/a682401.html

Isoniazid

pronounced as (eye soe nye' a zid)

IMPORTANT WARNING:

Isoniazid may cause severe and sometimes fatal liver damage. Tell your doctor if you have or have ever had liver disease, if you drink or have ever drunk large amounts of alcohol, or if you are using or have ever abused injectable street drugs. If you experience any of the following symptoms, call your doctor immediately: excessive tiredness, weakness, lack of energy, loss of appetite, nausea, vomiting, dark yellow or brown urine, yellowing of the skin or eyes, pain in the upper right part of the stomach, or flu-like symptoms.

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to isoniazid.

Why is this medication prescribed?

Isoniazid is used with other drugs to treat tuberculosis (TB; a serious infection that affects the lungs and sometimes other parts of the body). Isoniazid is also used with other drugs to treat people with latent (resting or nongrowing) TB including those in close contact with people who have active TB, a positive tuberculin skin test, human immunodeficiency virus (HIV), and those with pulmonary fibrosis (scarring of the lungs with an unknown cause). Isoniazid is in a class of medications called antituberculosis agents. It works by killing the bacteria that cause tuberculosis.

How should this medicine be used?

Isoniazid comes as a tablet and a solution (liquid) to take by mouth without food. Isoniazid is usually is taken once a day; it may also be taken one, two, or three times weekly. Take isoniazid at around the same time every scheduled day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take isoniazid exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Your doctor may tell you to take isoniazid for 6 months or longer. Continue to take isoniazid even if you feel well. Do not skip doses or stop taking isoniazid without talking to your doctor. Stopping isoniazid too soon may cause bacteria to become resistant to antibiotics.

Other uses for this medicine

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before taking isoniazid,

  • tell your doctor and pharmacist if you are allergic to isoniazid, any other medications, or any of the ingredients in isoniazid tablets or oral solution. Ask your pharmacist for a list of the ingredients.
  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take while taking isoniazid. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • the following nonprescription product may interact with isoniazid: acetaminophen. Be sure to let your doctor and pharmacist know that you are taking this medication before you start taking isoniazid. Do not start this medication while taking isoniazid without discussing with your healthcare provider.
  • in addition to the conditions listed in the IMPORTANT WARNING section, tell your doctor if you have or have ever had kidney disease; diabetes; tingling, burning, and pain in the fingers or toes (peripheral neuropathy); or human immunodeficiency virus (HIV).
  • tell your doctor if you are pregnant or plan to become pregnant. If you become pregnant while taking isoniazid, call your doctor.
  • you should know that you should not drink alcohol while taking this drug.

What special dietary instructions should I follow?

You will need to avoid eating foods beverages that contain very high amounts of tyramine or histamine during your treatment with isoniazid. These foods and beverages include certain cheeses, red wine, and certain fish (e.g., tuna, other tropical fish). Talk to your doctor or dietitian about which foods you should avoid during your treatment or if you do not feel well after eating or drinking certain foods while taking isoniazid.

What should I do if I forget a dose?

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can this medication cause?

Isoniazid may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • upset stomach
  • diarrhea (when taking solution)

If you experience any of the following symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately:

  • eye pain
  • changes in vision
  • numbness or tingling in the hands and feet
  • rash
  • fever
  • swollen glands
  • sore throat
  • unusual bleeding or bruising
  • ongoing pain that begins in the stomach but may spread to the back

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (https://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Dispose of unneeded medications in a way so that pets, children, and other people cannot take them. Do not flush this medication down the toilet. Use a medicine take-back program. Talk to your pharmacist about take-back programs in your community. Visit the FDA's Safe Disposal of Medicines website https://goo.gl/c4Rm4p for more information.

Keep all medication out of sight and reach of children as many containers are not child-resistant. Always lock safety caps. Place the medication in a safe location – one that is up and away and out of their sight and reach. https://www.upandaway.org

In case of emergency/overdose

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include the following:

  • nausea
  • vomiting
  • dizziness
  • slurred speech
  • vision problems

What other information should I know?

Before having any laboratory test, tell your doctor and the laboratory personnel that you are taking isoniazid.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

Keep a written list of all of the prescription and nonprescription (over-the-counter) medicines, vitamins, minerals, and dietary supplements you are taking. Bring this list with you each time you visit a doctor or if you are admitted to the hospital. You should carry the list with you in case of emergencies.

Brand names

  • Hyzyd®
  • INH®
  • Laniazid®
  • Nydrazid®
  • Rimifon®
  • Stanozide®
  • Tubizid®

Brand names of combination products

  • IsonaRif® (containing Isoniazid, Rifampin)
  • Rifamate® (containing Isoniazid, Rifampin)
  • Rifater® (containing Isoniazid, Pyrazinamide, Rifampin)

This branded product is no longer on the market. Generic alternatives may be available.

Last Revised - 12/15/2016