Why is this medication prescribed?
Thioguanine is used to treat acute myeloid leukemia (AML; a type of cancer that begins in the white blood cells). Thioguanine is in a class of medications known as purine analogs. It works by slowing or stopping the growth of cancer cells in your body.
How should this medicine be used?
Thioguanine comes as a tablet to take by mouth usually once a day. The length of treatment depends on the types of drugs you are taking, how well your body responds to them, and the type of cancer you have. Take thioguanine at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take thioguanine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Your doctor may increase or decrease your dose of thioguanine during your treatment. This depends on how well the medication works for you and on the side effects that you experience. Talk to your doctor about how you are feeling during your treatment. Continue to take thioguanine even if you feel well. Do not stop taking thioguanine without talking to your doctor
Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.
Other uses for this medicine
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
What special precautions should I follow?
Before taking thioguanine,
- tell your doctor and pharmacist if you are allergic to thioguanine, any other medications, or any of the ingredients in thioguanine tablets. Ask your pharmacist for a list of the ingredients.
- tell your doctor if you have already taken thioguanine or mercaptopurine to treat your cancer. Your doctor may tell you not to take thioguanine if either of these medications did not work well against your cancer in the past.
- tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take while taking thioguanine. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- tell your doctor if you have or have ever had liver disease.
- tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. You should not become pregnant or breast-feed while you are receiving thioguanine. If you become pregnant while receiving thioguanine, call your doctor. Thioguanine may harm the fetus.
- do not have any vaccinations without talking to your doctor.
- you should know that the risk that you will develop serious side effects of thioguanine may be higher if you have a genetic (inherited) risk factor. Your doctor may order tests before or during your treatment to see if you have this risk factor.
What special dietary instructions should I follow?
Unless your doctor tells you otherwise, continue your normal diet.
Drink plenty of fluids during your treatment with thioguanine.
What should I do if I forget a dose?
Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
What side effects can this medication cause?
Thioguanine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- nausea
- vomiting
- loss of appetite or weight
- sores in the mouth and throat
- headache
Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:
- unusual tiredness or weakness
- unusual bleeding or bruising
- yellowing of the skin or eyes
- flu-like symptoms
- swelling of the stomach area
- stomach pain, particularly in the right part of the stomach
- swelling of the face, arms, hands, feet, ankles or lower legs
- bloody vomit
- black, tarry or bloody stools
- fever, sore throat, ongoing cough and congestion, or other signs of infection
- shortness of breath
- lightheadedness
Thioguanine may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (https://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).
What should I know about storage and disposal of this medication?
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).
Dispose of unneeded medications in a way so that pets, children, and other people cannot take them. Do not flush this medication down the toilet. Use a medicine take-back program. Talk to your pharmacist about take-back programs in your community. Visit the FDA's Safe Disposal of Medicines website https://goo.gl/c4Rm4p for more information.
Keep all medication out of sight and reach of children as many containers are not child-resistant. Always lock safety caps. Place the medication in a safe location – one that is up and away and out of their sight and reach. https://www.upandaway.org
In case of emergency/overdose
In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.
Symptoms of overdose may include the following:
- nausea
- vomiting
- excessive sweating
- unusual tiredness or weakness
- unusual bleeding or bruising
- fever, sore throat, ongoing cough and congestion, or other signs of infection
What other information should I know?
Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your body's response to thioguanine.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
Keep a written list of all of the prescription and nonprescription (over-the-counter) medicines, vitamins, minerals, and dietary supplements you are taking. Bring this list with you each time you visit a doctor or if you are admitted to the hospital. You should carry the list with you in case of emergencies.
Brand names
- Tabloid®
Other names
- 2-Amino-6-mercaptopurine
- 6-TG
- 6-Thioguanine