Sulopenem etzadroxil and Probenecid

Sulopenem etzadroxil and probenecid comes as a tablet to take by mouth. It is usually taken with food two times a day for 5 days. Take sulopenem etzadroxil and probenecid at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take sulopenem etzadroxil exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Sulopenem etzadroxil and probenecid may increase the risk of gout attacks or kidney stones, especially in patients with history of gout. It is important to drink plenty of water while receiving sulopenem etzadroxil and probenecid therapy. Your doctor may also ask you to take an additional medication to help prevent this from occurring.

You should begin to feel better during the first few days of treatment with sulopenem etzadroxil and probenecid. If your symptoms do not improve or get worse, call your doctor.

Take sulopenem etzadroxil and probenecid until you finish the prescription, even if you feel better. If you stop taking sulopenem etzadroil and probenecid too soon or skip doses, your infection may not be completely treated and the bacteria may become resistant to antibiotics.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking sulopenem etzadroxil and probenecid,

• tell your doctor and pharmacist if you are allergic to sulopenem etzadroxil, probenecid, other beta-lactam antibacterials (e.g. penicillin, amoxicillin, ampicillin, cephalexin, cefazolin, meropenem, aztreonam, etc.), any other medications, or any of the ingredients in sulopenem etzadroxil and probenecid tablets. Ask your pharmacist or check the Medication Guide for a list of the ingredients.
• some medications should not be taken with sulopenem etzadroxil and probenecid. Other medications may cause dosing changes or extra monitoring when taken with sulopenem etzadroxil and probenecid. Make sure you have discussed any medications you are currently taking or plan to take before starting sulopenem etzadroxil and probenecid with your doctor and pharmacist. Before starting, stopping, or changing any medications while taking sulopenem etzadroxil and probenecid, please get the advice of your doctor or pharmacist.
• the following nonprescription or herbal products may interact with sulopenem etzadroxil and probenecid: naproxen. Be sure to let your doctor and pharmacist know that you are taking these medications before you start taking sulopenem etzadroxil and probenecid. Do not start any of these medications while taking sulopenem etzadroxil and probenecid without discussing with your healthcare provider.
• tell your doctor if you have or have had any disorder of the blood such as anemia, low platelets, or low blood cell counts or have kidney stones. Your doctor will probably tell you not to take sulopenem etzadroxil and probenecid.
• tell your doctor if you have or have ever had clostridum difficile (c. diff)-associated diarrhea (CDAD; a type of diarrhea illness caused by clostridum difficile bacteria), gout or kidney disease.
• tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking sulopenem etzadroxil and probenecid, call your doctor.

Unless your doctor tells you otherwise, continue your normal diet.

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

Sulopenem etzadroxil and probenecid may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• diarrhea or loose stool
• nausea
• headache
• vomiting
• stomach pain

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:

• severe or persistent diarrhea up to 2 months after finishing sulopenem etzadroxil and probenecid that may also come with a fever, severe belly pain, nausea, weight loss
• itching, redness or irritation in the vagina; vaginal discharge that is white and cloudy or thin and watery and has an odor; pain when urinating; pain during sexual intercourse
• pain in lower back, side or groin; urge to urinate or urinating frequently; fever; cloudy or bloody urine
• sudden and severe pain in one or more joints. often occurring at night; swelling and/or redness, warmth, or tenderness in the joint

Sulopenem etzadroxil and probenecid may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (https://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. https://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (https://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Keep all appointments with your doctor.

Do not let anyone else take your medication. Your prescription is probably not refillable. If you still have symptoms of infection after you finish the sulopenem etzadroxil and probenecid, call your doctor.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.