Zenocutuzumab-zbco Injection

Zenocutuzumab-zbco injection is used to treat certain types of non-small cell lung cancer (NSCLC) and pancreatic cancer. Zenocutuzumab-zbco is in a class of medications called immunotherapy. It works by stopping the growth of cancer cells.

Zenocutuzumab-zbco comes as a solution (liquid) to be injected into a vein over 4 hours by a doctor or nurse in a hospital or medical facility. It is usually injected once every 2 weeks. Your doctor will decide the length of your treatment based on how well your body responds to the medication and the side effects that you experience.

Zenocutuzumab-zbco injection may cause serious or life-threatening reactions while the medication is being given. A doctor or nurse will watch you closely while you receive each dose of zenocutuzumab-zbco injection and for at least 1 hour after your first dose. Your doctor may give you other medications before you receive zenocutuzumab-zbco injection to prevent certain side effects. Tell your doctor immediately if you experiences any of the following symptoms during or after your infusion: chills or shaking; fever; itching or rash; feeling lightheaded or faint; dizziness; flushing, nausea, vomiting, or diarrhea; swelling of the face, eyes, mouth, throat, tongue, or lips; difficulty breathing or swallowing; chest pain; back or neck pain; shortness of breath or wheezing; or feeling numbness or tingling. Your doctor may need to slow down your infusion or delay or stop your treatment if you experience these or other side effects.

Ask your doctor or pharmacist for a copy of the manufacturer's information for the patient.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before receiving zenocutuzumab-zbco injection,

• tell your doctor and pharmacist if you are allergic to zenocutuzumab-zbco injection, any other medications, or any of the ingredients in zenocutuzumab-zbco injection. Ask your pharmacist for a list of the ingredients.
• tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take.
• tell your doctor if you have or have ever had lung or breathing problems other than lung cancer; heart failure or any other heart problems; lower than normal levels of sodium, magnesium, or phosphate in your blood; or liver problems.
• tell your doctor if you are breastfeeding or plan to breastfeed. You should not breastfeed while receiving zenocutuzumab-zbco injection and for 2 months after your final dose.
• if you are having surgery, including dental surgery, tell the doctor or dentist that you are receiving zenocutuzumab-zbco injection.

Unless your doctor tells you otherwise, continue your normal diet.

If you miss an appointment to receive zenocutuzumab-zbco injection, call your doctor as soon as possible.

Zenocutuzumab-zbco injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• diarrhea
• nausea
• vomiting
• constipation
• stomach swelling or pain
• mouth sores
• unusual tiredness and weakness
• muscle, joint, or bone pain
• decreased appetite
• dry skin
• feeling anxious

Some side effects can be serious. If you experience any of these symptoms or those listed in the HOWsection, call your doctor immediately or get emergency medical treatment:

• new or worsening trouble breathing, shortness of breath, cough, or fever
• swelling of the ankles, or lower legs; sudden weight gain; dizziness; loss of consciousness; or fast, irregular, or pounding heartbeat
• nosebleeds or other unusual bleeding or bruising

Zenocutuzumab-zbco injection may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (https://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests before and during your treatment to see if it's safe for you to receive zenocutuzumab-zbco injection and to check your body's response to zenocutuzumab-zbco injection.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.