URL of this page: https://medlineplus.gov/druginfo/meds/a622039.html

Treprostinil Oral Inhalation

pronounced as (tre pros' ti nil)

Why is this medication prescribed?

Treprostinil oral inhalation is used to treat certain kinds of pulmonary arterial hypertension (PAH; high blood pressure in the vessels carrying blood to the lungs, causing shortness of breath, dizziness, and tiredness). Treprostinil oral inhalation is also used to treat pulmonary hypertension associated with interstitial lung disease (PH-ILD; high blood pressure in the lungs resulting from a lung disease that involves inflammation and scarring of the lungs). Treprostinil may improve the ability to exercise and slow the worsening of symptoms in patients with PAH and PH-ILD. Treprostinil is in a class of medications called vasodilators and platelet-aggregation inhibitors. It works by relaxing the blood vessels, including those in the lungs, and improving blood flow.

How should this medicine be used?

Treprostinil oral inhalation comes in ampules that contain a solution (liquid) to inhale by mouth using a special inhaler device. It is usually inhaled four times a day, approximately every 4 hours, during waking hours. Use treprostinil exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor.

Your doctor or nurse will show you how to use treprostinil inhalation solution with your delivery device. Your doctor will also tell you how many breaths you will need to inhale for each dose. Carefully read the manufacturer's instructions that describe how to prepare and inhale a dose of treprostinil and how to use the delivery device. Be sure that you understand these directions. Ask your healthcare provider if you have any questions about how to prepare or inhale this medication or how to use or store the device. At the end of each day, dispose of any solution remaining in the delivery device and carefully follow the manufacturer's instructions for cleaning the delivery system components. Do not mix other medications with treprostinil solution.

Do not swallow treprostinil solution. If treprostinil solution gets on your skin or in your eyes, rinse your skin or eyes with water right away.

The effects of the medication may not last more than 4 hours. You may need to adjust the timing of your doses to cover your planned activities.

Treprostinil solution is used with a specific inhaler device. Make sure you can get another delivery device to use right away if your device does not work for any reason. Be sure to ask your healthcare provider what do if your delivery device stops working properly.

Treprostinil may control the symptoms of PAH and PH-ILD, but does not cure it. Continue to use treprostinil even if you feel well. Do not stop using treprostinil without talking to your doctor. If you suddenly stop using treprostinil, your symptoms may get worse. Your doctor will probably decrease your dose gradually.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient and a copy of the Instructions for Use for the inhaler device.

Other uses for this medicine

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before using treprostinil inhalation,

  • tell your doctor and pharmacist if you are allergic to treprostinil (Orenitram, Remodulin, Tyvaso), any other medications, or any of the ingredients in treprostinil oral inhalation. Ask your pharmacist for a list of the ingredients.
  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: gemfibrozil and rifampin (Rifadin, Rimactane). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with treprostinil, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
  • tell your doctor if you have or have ever had low blood pressure, bleeding problems, or liver problems.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while using treprostinil inhalation, call your doctor.
  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are using treprostinil inhalation.

What special dietary instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What should I do if I forget a dose?

Take the missed dose as soon as you remember it and call your doctor.

What side effects can this medication cause?

Treprostinil may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • cough
  • throat irritation or pain
  • headache
  • nausea
  • diarrhea
  • flushing
  • muscle, jaw, or bone pain

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:

  • unusual bleeding or bruising
  • dizziness or fainting

Treprostinil inhalation may cause other side effects. Call your doctor if you have any unusual problems while using this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Keep the ampules sealed in the foil pouch until you are ready to use them. Store it at room temperature and away from light, excess heat and moisture (not in the bathroom). Dispose of unused treprostinil ampules if not used within 7 days after opening the foil pouch. Opened ampules of treprostinil that have been transferred to the delivery device may be stored in the delivery device for up to one day (24 hours), after that time the solution should be discarded.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of emergency/overdose

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include:

  • headache
  • nausea
  • vomiting
  • diarrhea
  • dizziness or fainting

What other information should I know?

Keep all appointments with your doctor.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Brand names

  • Tyvaso®
Last Revised - 05/15/2022