Rimegepant

Rimegepant is used to prevent and treat migraine headaches (severe, throbbing headaches that sometimes are accompanied by nausea and sensitivity to sound or light). Rimegepant is in a class of medications called calcitonin gene-related peptide receptor antagonists. It works by blocking the action of a certain natural substance in the body that causes migraine headaches.

Rimegepant comes as an orally disintegrating tablet (ODT) to place on or underneath the tongue and allow to dissolve. If used to prevent a migraine, take every other day. If used to treat a migraine, take as a single dose at the first sign of a migraine headache. Do not take more than one dose in a 24-hour period to treat a migraine. Your doctor will tell you the maximum number of migraine headaches you should treat with rimegepant tablets in a 30-day period.

Take rimegepant exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Do not push the orally disintegrating tablet through the foil packaging. Instead, use dry hands to peel back the foil. Immediately take out the tablet and place it on or under your tongue. The tablet will quickly dissolve and can be swallowed with saliva. No water is needed to swallow disintegrating tablets.

Call your doctor if your headaches do not get better or occur more often after taking rimegepant.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking rimegepant,

• tell your doctor or pharmacist if you are allergic to this medication, any part of this medication, or any other medications, foods or substances. Tell your doctor or pharmacist about the allergy and what symptoms you had.
• some medications should not be taken with rimegepant. Other medications may cause dosing changes or extra monitoring when taken with rimegepant. Make sure you have discussed any medications you are currently taking or plan to take before starting rimegepant with your doctor and pharmacist. Before starting, stopping, or changing any medications while taking rimegepant, please get the advice of your doctor or pharmacist.
• the following nonprescription or herbal products may interact with rimegepant: St. John's Wort. Be sure to let your doctor and pharmacist know that you are taking these medications before you start taking rimegepant. Do not start any of these medications while taking rimegepant without discussing with your healthcare provider.
• tell your doctor if you have or have ever had kidney or liver problems, hypertension (high blood pressure), or Raynaud's Phenomenon (condition that causes reduced blood flow to the fingers and toes, often in response to cold or stress).
• tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking rimegepant, call your doctor.

Talk to your doctor about eating grapefruit and drinking grapefruit juice while taking this medication.

Rimegepant may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• nausea
• stomach pain
• indigestion

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:

• hives; rash; itiching; swelling of the face, eyes, mouth, throat, tongue, or lips; shortness of breath; or difficulty breathing
• numb, cold, painful, or discolored fingers or toes

Rimegepant may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (https://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Keep all medication out of sight and reach of children as many containers are not child-resistant. Always lock safety caps. Place the medication in a safe location – one that is up and away and out of their sight and reach. https://www.upandaway.org

Dispose of unneeded medications in a way so that pets, children, and other people cannot take them. Do not flush this medication down the toilet. Use a medicine take-back program. Talk to your pharmacist about take-back programs in your community. Visit the FDA's Safe Disposal of Medicines website https://goo.gl/c4Rm4p for more information.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Keep all appointments with your doctor.

You should keep a headache diary by writing down when you have headaches and when you take rimegepant.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

Keep a written list of all of the prescription and nonprescription (over-the-counter) medicines, vitamins, minerals, and dietary supplements you are taking. Bring this list with you each time you visit a doctor or if you are admitted to the hospital. You should carry the list with you in case of emergencies.

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