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URL of this page: https://medlineplus.gov/druginfo/meds/a618006.html

Letermovir

pronounced as (le term' oh vir)

Why is this medication prescribed?

Letermovir is used to help prevent cytomegalovirus (CMV) infection and disease in certain people who have received a hematopoietic stem-cell transplant (HSCT; a procedure that replaces diseased bone marrow with healthy bone marrow) and are at increased risk of developing a CMV infection. Letermovir is also used to help prevent CMV infection and disease in certain people who have received a kidney transplant and are at increased risk of developing a CMV infection. Letermovir is in a class of medications called antivirals. It works by slowing the growth of CMV.

How should this medicine be used?

Letermovir comes as a tablet and pellets to take by mouth. It is usually taken once a day. Letermovir tablets may be taken with or without food. Letermovir pellets must be mixed with a soft food and taken by mouth (without chewing) or given through a feeding tube. Your doctor will probably tell you to start taking letermovir after you receive the transplant and to stop taking the medication 100 or 200 days after the transplant. Take letermovir at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take letermovir exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the tablets whole; do not split, chew, or crush them.

To take the pellets, open the packet and sprinkle the pellets on 1 to 3 teaspoonfuls of a cold or room temperature soft food such as applesauce, yogurt, or pudding. Mix the soft food and the pellets gently together and take the entire mixture within 10 minutes of sprinkling the pellets on the food. Do not chew or crush the pellets.

Letermovir pellets may be given through a feeding tube. If you have a feeding tube, ask your doctor how you should take letermovir.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

Other uses for this medicine

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before taking letermovir,

  • tell your doctor and pharmacist if you are allergic to letermovir, any other medications, or any of the ingredients in letermovir tablets. Ask your pharmacist for a list of the ingredients.
  • some medications should not be taken with letermovir. Other medications may cause dosing changes or extra monitoring when taken with letermovir injection. Make sure you have discussed any medications you are currently taking or plan to take before starting letermovir with your doctor and pharmacist. Before starting, stopping, or changing any medications while taking letermovir, please get the advice of your doctor or pharmacist.
  • the following nonprescription or herbal products may interact with letermovir: St. John's wort; omeprazole (Prilosec). Be sure to let your doctor and pharmacist know that you are taking these medications before you start letermovir. Do not start any of these medications while taking letermovir without discussing with your healthcare provider.
  • tell your doctor if you have or have ever had kidney or liver disease.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking letermovir, call your doctor.
  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking letermovir.

What special dietary instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What should I do if I forget a dose?

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can this medication cause?

Letermovir may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • nausea
  • vomiting
  • diarrhea
  • abdominal pain
  • swelling of your arms or legs
  • headache
  • extreme tiredness
  • cough

Some side effects can be serious. If you experience any of these symptoms call your doctor immediately:

  • fast or irregular heartbeat; feeling weak or dizzy, shortness of breath, or chest pain

Letermovir may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (https://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Keep all medication out of sight and reach of children as many containers are not child-resistant. Always lock safety caps. Place the medication in a safe location – one that is up and away and out of their sight and reach. https://www.upandaway.org

Dispose of unneeded medications in a way so that pets, children, and other people cannot take them. Do not flush this medication down the toilet. Use a medicine take-back program. Talk to your pharmacist about take-back programs in your community. Visit the FDA's Safe Disposal of Medicines website https://goo.gl/c4Rm4p for more information.

In case of emergency/overdose

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

What other information should I know?

Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your body's response to letermovir.

Keep a written list of all of the prescription and nonprescription (over-the-counter) medicines, vitamins, minerals, and dietary supplements you are taking. Bring this list with you each time you visit a doctor or if you are admitted to the hospital. You should carry the list with you in case of emergencies.

Brand names

  • Prevymis®
Last Revised - 12/15/2024