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Fosaprepitant Injection

pronounced as (fos" a pre' pi tant)

Why is this medication prescribed?

Fosaprepitant injection is used along with other medications to prevent nausea and vomiting in adults that may occur within 24 hours after receiving cancer chemotherapy treatment. It is also used along with other medications to prevent delayed nausea and vomiting that may occur several days after receiving certain chemotherapy medications. Fosaprepitant injection is not used to treat nausea and vomiting that you already have. Fosaprepitant is in a class of medications called antiemetics. It works by blocking the action of neurokinin, a natural substance in the brain that causes nausea and vomiting.

How should this medicine be used?

Fosaprepitant injection comes as a powder to be mixed with liquid to be injected intravenously (into a vein) by a doctor or nurse in a medical facility. It is usually given by intravenous infusion over 20 to 30 minutes, beginning about 30 minutes before the start of chemotherapy.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

Other uses for this medicine

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before using fosaprepitant injection,

  • tell your doctor and pharmacist if you are allergic to fosaprepitant, aprepitant (Emend), any other medications, or any of the ingredients in fosaprepitant injection. Ask your pharmacist for a list of the ingredients.
  • tell your doctor if you are taking pimozide (Orap). Your doctor will probably tell you not to use fosaprepitant injection if you are taking this medication.
  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven); certain antifungals such as itraconazole (Sporanox) and ketoconazole (Nizoral); benzodiazepines such as alprazolam (Xanax), midazolam (Versed), and triazolam (Halcion); certain cancer chemotherapy medications such as ifosfamide (Ifex), vinblastine, and vincristine (Marquibo); carbamazepine (Tegretol, Teril); clarithromycin (Biaxin, in Prevpac); diltiazem (Cardizem, Dilacor); certain HIV protease inhibitors such as nelfinavir (Viracept) and ritonavir (Norvir); hormonal contraceptives (birth control pills, patches, rings, and injections); nefazodone; oral steroids such as dexamethasone and methylprednisolone (Medrol); phenytoin (Dilantin, Phenytek); rifampin (Rifadin, Rimactane); and troleandomycin (TAO, no longer available in the U.S.). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with fosaprepitant, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
  • tell your doctor if you have or have ever had liver disease.
  • tell your doctor if you are pregnant or plan to become pregnant. If you are taking birth control medications during treatment with fosaprepitant you should also use an additional method of birth control to avoid pregnancy during treatment with fosaprepitant and for one month after your final dose. Talk to your doctor about birth control methods while you are receiving fosaprepitant and after treatment. If you become pregnant while using fosaprepitant, call your doctor.
  • tell your doctor if you are breastfeeding.

What special dietary instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What side effects can this medication cause?

Fosaprepitant may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  1. tiredness or weakness
  2. diarrhea
  3. pain, redness, or swelling at the injection site

Some side effects can be serious. If you experience any of these symptoms, stop using fosaprepitant and call your doctor immediately or get emergency medical treatment:

  1. flushing
  2. rash
  3. shortness of breath
  4. difficulty breathing or swallowing
  5. hives
  6. itching
  7. peeling or blistering of the skin

Fosaprepitant may cause other side effects. Call your doctor if you have any unusual problems while using this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

In case of emergency/overdose

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

What other information should I know?

Keep all appointments with your doctor.

Do not let anyone else use your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Brand names

  • Emend®
Last Revised - 10/15/2017