URL of this page: https://medlineplus.gov/druginfo/meds/a614060.html

Olaparib

pronounced as (oh lap' a rib)

Why is this medication prescribed?

Olaparib is used to treat ovarian cancer (cancer that begins in the female reproductive organs where eggs are formed) in people with a specific gene who have not improved or who have worsened after treatment with at least three other therapies. Olaparib is a polyadenosine 5'-diphosphoribose polymerase (PARP) enzyme inhibitor. It works by killing cancer cells.

How should this medicine be used?

Olaparib comes as a capsule to take by mouth twice daily. Take olaparib at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take olaparib exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the capsules whole; do not open, chew, or dissolve them.

Your doctor may decrease your dose of olaparib or tell you to stop taking olaparib for a period of time during your treatment. This will depend on how well the medication works for you and any side effects you may experience. Be sure to tell your doctor how you are feeling during your treatment with olaparib.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

Other uses for this medicine

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before taking olaparib,

  • tell your doctor and pharmacist if you are allergic to olaparib, any other medications, or any of the ingredients in olaparib capsules. Ask your pharmacist for a list of the ingredients.
  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: antibiotics such as ciprofloxacin (Cipro), clarithromycin (Biaxin, Prevpac), erythromycin (E.E.S., Erythrocin, others), nafcillin, and telithromycin (Ketek); antifungals such as fluconazole (Diflucan), itraconazole (Onmel, Sporanox), ketoconazole (Extina, Nizoral, Xolegel), posaconazole (Noxafil), and voriconazole (Vfend); aprepitant (Emend); certain medications to treat seizures such as carbamazepine (Carbatrol, Epitol, Tegretol, Teril), and phenytoin (Dilantin, Phenytek); bosentan (Tracleer); crizotinib (Xalkori); diltiazem (Cardizem, Cartia, Dilacor, Tiazac, others); certain medications to treat hepatitis C such as boceprevir (Victrelis) and telaprevir (Incivek); certain medications to treat human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS) such as atazanavir (Reyataz), darunavir (Prezista), efavirenz (Sustiva, in Atripla), etravine (Intelence), fosamprenavir (Lexiva), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, in Kaletra), and saquinavir (Invirase); imatinib (Gleevec); modafinil (Provigil); nefazodone; other chemotherapy medications for cancer, rifampin (Rifadin, Rimactane), and verapamil (Calan, Covera, Verelan, in Tarka). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • tell your doctor what herbal products you are taking, especially St. John's wort. You should not take St. John's wort while you are taking olaparib.
  • tell your doctor if you have or have ever had have lung or breathing problems, or kidney or liver disease.
  • tell your doctor if you are pregnant or plan to become pregnant. You should not become pregnant while you are taking olaparib. You should use effective birth control to prevent pregnancy during your treatment with olaparib and for at least 1 month after your last dose of medication. Talk to your doctor about birth control methods that will work for you. If you become pregnant while taking olaparib, call your doctor immediately. Olaparib may harm the fetus.
  • tell your doctor if you are breastfeeding. Do not breastfeed while you are taking olaparib.

What special dietary instructions should I follow?

Do not eat grapefruit or Seville oranges (sometimes used in marmalades), or drink grapefruit juice while taking this medication.

What should I do if I forget a dose?

Skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can this medication cause?

Olaparib may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • nausea
  • vomiting
  • diarrhea
  • heartburn
  • headache
  • decreased appetite
  • muscle, joint, or back pain
  • stomach pain or discomfort
  • taste changes
  • anxiety
  • depression
  • dry skin
  • itching
  • rash
  • difficulty falling asleep or staying asleep
  • sore throat, runny nose, or other cold symptoms
  • pain urinating

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:

  • fever, cough, or wheezing
  • shortness of breath
  • weakness
  • extreme tiredness
  • weight loss
  • numbness, tingling, or burning sensation in the hands or feet
  • unusual bruising or bleeding
  • pale skin
  • blood in urine or stool

Olaparib may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

In case of emergency/overdose

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

What other information should I know?

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to olaparib.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Brand names

  • Lynparza®
Last Revised - 02/15/2015