Palonosetron Injection

Palonosetron injection is used to prevent nausea and vomiting that may occur after receiving cancer chemotherapy or surgery. Palonosetron injection is in a class of medications called 5-HT₃ receptor antagonists. It works by blocking the action of serotonin, a natural substance that may cause nausea and vomiting.

Palonosetron injection comes as a solution (liquid) to be injected intravenously (into a vein) by a healthcare provider in a hospital or clinic. Palonosetron is given before chemotherapy or surgery.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before receiving palonosetron injection,

• tell your doctor or pharmacist if you are allergic to this medication, any part of this medication, or any other medications, foods or substances. Tell your doctor or pharmacist about the allergy and what symptoms you had.
• tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take while receiving palonosetron injection. Your doctor may need to change the doses of your medications or monitor you more carefully for side effects.
• tell your doctor if you have or have ever had any medical condition.
• tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while receiving palonosetron injection, call your doctor.

Unless your doctor tells you otherwise, continue your normal diet.

Palonosetron injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• headache
• constipation
• pain, redness, or swelling at the injection site

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:

• rash, itching, hives; difficulty breathing or swallowing; swelling of the face
• chest pain; dizziness or lightheadedness; fainting
• changes in heart beat or heart rhythm
• fast, slow or irregular heartbeat
• agitation, confusion; nausea, vomiting, and diarrhea; loss of coordination; stiff or twitching muscles; seizures; coma (loss of consciousness)

Palonosetron injection may cause other side effects. Call your doctor if you have any unusual problems while receiving this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (https://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep all appointments with your doctor.

Keep a written list of all of the prescription and nonprescription (over-the-counter) medicines, vitamins, minerals, and dietary supplements you are taking. Bring this list with you each time you visit a doctor or if you are admitted to the hospital. You should carry the list with you in case of emergencies.

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