From the lab - latest research from NIH

Testing Malaria-Resistant Mosquitoes

Malaria is a serious disease that affects 200 million people every year and is found in tropical areas of the world. Malaria kills thousands of people (more than 400,000 in 2015), especially in developing countries. It spreads when an infected mosquito bites you.

Malaria drugs, insect-killing products called insecticides, and bed nets have reduced the number of malaria cases in some countries.

But new approaches are needed due to developing resistance to malaria drugs and resistance to insecticides in mosquitoes.

One approach involves changing the genes of some mosquitoes to make them resistant to malaria. Under experimental conditions in a lab, researchers mated malaria-resistant mosquitoes with regular mosquitoes.

The researchers found that the malaria-resistant mosquitoes were able to mate and spread the malaria-resistant gene in the lab population.

The study started with equal numbers of wild and genetically modified mosquitoes. By the end of the study, 90 percent of the mosquitoes, on average, carried the resistance trait.

This research provides evidence that malaria-resistant mosquitoes may be able to compete with regular (wild) mosquitoes. This means they may be able to spread the malaria-resistance gene to natural populations. While the study had promising results, more research is needed to see whether the approach will prevent the spread of the disease.

Sources: NIH Research Matters: NIH Testing Malaria Resistance in Mosquitoes opens in new window; World Health Organization: Key Malaria Facts opens in new window

Winter 2018 Issue: Volume 12 Number 5 Page 29b
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