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Asthma: NIH-Sponsored Research and Clinical Trials

NIH-Sponsored Research

  • Asthma in the Inner City: Recognizing that asthma severity in inner-city children is disproportionately high, the National Institute of Allergy and Infectious Diseases (NIAID) and the National Institute of Environmental Health Sciences (NIEHS) has sponsored research to reduce the public health burden that asthma presents in inner-city populations. Beginning in 1991, NIAID has supported three consecutive inner-city asthma research programs, which have been successful in reducing asthma severity in children. The latest study—the Inner-city Asthma Consortium (ICAC)—consists of two phases: Phase I from 2002-2009 and Phase II from 2009-2014. There are 11 research sites nationally involved in ICAC. In one of two clinical trials, the results of the study clearly demonstrated that asthma, even in inner-city populations, can be well-controlled using current asthma treatment guidelines.
  • Mold and Childhood Asthma: Infants who live in “moldy” homes are three times more likely to develop asthma by age 7—an age that children can be accurately diagnosed with the condition, according to a recent study funded, in part, by the National Institute of Environmental Health Sciences (NIEHS). “Early life exposure to mold seems to play a critical role in childhood asthma development,” says Tiina Reponen, Ph.D., lead study author and University of Cincinnati (UC) professor of environmental health. “Genetic factors are also important to consider in asthma risk, since infants whose parents have an allergy or asthma are at the greatest risk of developing asthma.” UC and Cincinnati Children’s Hospital Medical Center researchers analyzed seven years of comprehensive data for 176 children to evaluate the effects of mold exposure in early life. The children were part of the Cincinnati Childhood Allergy and Air Pollution Study (CCAAPS), a long-term population-based study that included more than 700 children from the Greater Cincinnati area.
  • An African American Asthma Gene: Genetics researchers have identified a gene that is linked specifically and only to individuals of African descent who have asthma. The gene variant was identified in a large genome-wide association study (GWAS) carried out by a consortium of nine research organizations that also identified other genes that were common across multiple ethnic groups. The consortium was formed, in part, due to the difficulty of finding asthma risk factors without large amounts of pooled data. The study was funded by the National Heart, Lung, and Blood Institute.

Clinical Trials

The National Heart, Lung, and Blood Institute (NHLBI) supports studies that explore:

  • How new technologies can improve asthma care
  • How certain medicines and other therapies can help treat asthma and improve quality of life
  • What factors cause asthma to develop

For more information about clinical trials related to asthma, talk with your doctor. You also can visit the following Web sites to learn more about clinical research and to search for clinical trials:

For more information about clinical trials for children, visit the NHLBI’s Children and Clinical Studies Web page.


Read More "Asthma" Articles

Turning Discovery Into Health – Asthma / Chronic Diseases: Asthma and You / Asthma: NIH-Sponsored Research and Clinical Trials / Jackie Joyner-Kersee: Living with Asthma

Fall 2011 Issue: Volume 6 Number 3 Page 8