Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a genetic disorder that is most common in males. About 1 in 10 African American males in the United States has it. G6PD deficiency mainly affects red blood cells, which carry oxygen from the lungs to tissues throughout the body. The most common medical problem it can cause is hemolytic anemia. That happens when red blood cells are destroyed faster than the body can replace them.
If you have G6PD deficiency, you may not have symptoms. Symptoms happen if your red blood cells are exposed to certain chemicals in food or medicine, certain bacterial or viral infections, or stress. They may include:
- Dark urine
- Shortness of breath
- Enlarged spleen
- Rapid heart rate
A blood test can tell if you have it. Treatments include medicines to treat infection, avoiding substances that cause the problem with red blood cells, and sometimes transfusions.
NIH: National Library of Medicine
- Blood Count Tests: MedlinePlus Health Topic (National Library of Medicine) Also in Spanish
- G6PD Deficiency (Glucose-6-Phosphate Dehydrogenase) (For Parents) (Nemours Foundation)
- G6PD Test (National Library of Medicine) Also in Spanish
- Glucose-6-phosphate dehydrogenase deficiency (Medical Encyclopedia) Also in Spanish
- Glucose-6-Phosphate Dehydrogenase Deficiency Overview (Genetic and Rare Diseases Information Center)
- Glucose-6-phosphate dehydrogenase deficiency: MedlinePlus Genetics (National Library of Medicine)
- ClinicalTrials.gov: Glucosephosphate Dehydrogenase Deficiency (National Institutes of Health)
Journal Articles References and abstracts from MEDLINE/PubMed (National Library of Medicine)
- Article: Prevalence of G6PD deficiency and diagnostic accuracy of a G6PD point-of-care...
- Article: Evaluation of quantitative point-of-care test for measurement of glucose-6-phosphate dehydrogenase enzyme...
- Article: Factors hindering coverage of targeted mass treatment with primaquine in a...
- G6PD Deficiency -- see more articles
- Glucose-6-phosphate dehydrogenase (Medical Encyclopedia) Also in Spanish